Comparison of baseline characteristics of visual function and retinal anatomy in the rescue, reflect and reverse studies
| Rescue | Reflect | Reverse | |
| N subjects | 39 | 98 | 37 |
| N males (%) | 32 (82) | 78 (79.6) | 29 (78.4) |
| Age (years) at screening | |||
| Mean (SD) | 36.3 (16.5) | 32.1 (13.8) | 34.2 (15.2) |
| Min; max | 15; 69 | 15; 74 | 15; 67 |
| Duration of vision loss (days) | |||
| N eyes | 73 | 196 | 74 |
| Mean (SD) | 112.1 (42.8) | 222.8 (103.3) | 271.0 (59.5) |
| Min; max | 24; 179 | 0; 363 | 181; 364 |
| N eyes | 78 | 196 | 74 |
| BCVA (LogMAR) | |||
| Mean (SD) | 1.29 (0.56) | 1.55 (0.47) | 1.61 (0.46) |
| Min; max | −0.20; 2.51 | 0 ; 2.3 | 0.70; 3.17 |
| Contrast sensitivity (LogCS) | |||
| Mean (SD) | 0.62 (0.54) | 0.37 (0.46) | 0.30 (0.43) |
| Min; max | 0; 1.65 | 0; 1.35 | 0; 1.50 |
| GCL macular volume (mm3)* | |||
| Mean (SD) | 0.73 (0.17) | 0.62 (0.1) | 0.53 (0.066) |
| Min; max | 0.50; 1.28 | 0.35; 1.12 | 0.42; 0.72 |
| PMB RNFL thickness (µm)* | |||
| Mean (SD) | 34.8 (14.4) | 30.30 (13.8)† | 23.4 (6.7) |
| Min; max | 21.0; 123.0 | 10.0; 126.0 | 1.5; 39.5 |
| RNFL temporal quadrant (μm)* | |||
| Mean (SD) | 49.6 (20.9) | 39.66 (23.0)† | 28.2 (8.0) |
| Min; max | 24.5; 147.5 | 16.0; 183.0 | 13.5; 62.5 |
| Average RNFL thickness (µm)* | |||
| Mean (SD) | 99.1 (18.2) | 82.16 (28.98)† | 69.7 (18.1) |
| Min; max | 47.0; 162.0 | 37; 200 | 39.5; 116.5 |
| ETDRS total macular volume (mm3)* | |||
| Mean (SD) | 8.40 (0.47) | 8.00 (0.5) | 7.83 (0.36) |
| Min; max | 7.54; 9.58 | 6.2; 9.5 | 6.54; 8.75 |
*Average of screening and baseline values.
†A total of 194 eyes (missing data for 2 eyes).
BCVA, best-corrected visual acuity; ETDRS, Early-Treatment Diabetic Retinopathy Study; GCL, ganglion cell layer; LogCS, logarithm of contrast sensitivity; LogMAR, logarithm of the minimal angle of resolution; PMB, papillomacular bundle; RNFL, retinal nerve fibre layer.