Total RVO patients (N=312) | Patients age<60 (N=71) | Patients age≥60 (N=241) | P value | |
Demographics | ||||
Age (median (IQR)) | 71.00 (61.00, 78.25) | 54.00 (48.00, 57.00) | 74.00 (69.00, 80.00) | <0.001 |
BMI (median (IQR))* | 27.90 (24.32, 31.30) | 30.41 (26.63, 36.72) | 27.61 (24.09, 30.70) | <0.001 |
Sex (%) | ||||
Female | 164 (52.6) | 38 (53.5) | 126 (52.3) | 0.961 |
Race/ethnicity (%)† | ||||
White | 163 (52.6) | 36 (50.7) | 127 (53.1) | 0.822 |
Black | 48 (15.5) | 12 (16.9) | 36 (15.1) | 0.850 |
Hispanic | 84 (27.1) | 18 (25.4) | 66 (27.6) | 0.822 |
Other | 15 (4.8) | 5 (7.0) | 10 (4.2) | 0.347 |
Smoking status (%)‡ | ||||
Former or current | 87 (38.5) | 16 (36.4) | 71 (39.0) | 0.880 |
Type of RVO (%) | 0.341 | |||
CRVO (non-ischaemic) | 68 (21.8) | 18 (25.4) | 50 (20.7) | |
CRVO (ischaemic) | 68 (21.8) | 13 (18.3) | 55 (22.8) | |
Hemi-CRVO (non-ischaemic) | 14 (4.5) | 3 (4.2) | 11 (4.6) | |
Hemi-CRVO (ischaemic) | 21 (6.7) | 2 (2.8) | 19 (7.9) | |
BRVO (non-ischaemic) | 58 (18.6) | 18 (25.4) | 40 (16.6) | |
BRVO (ischaemic) | 83 (22.6) | 17 (23.9) | 66 (27.4) | |
Comorbidities (%) | ||||
Hypertension§ | 258 (83.8) | 50 (72.5) | 208 (87.0) | 0.007 |
Hypercholesterolaemia¶ | 175 (70.0) | 34 (68.0) | 141 (70.5) | 0.863 |
Diabetes** | 102 (39.5) | 22 (40.0) | 80 (39.4) | 1.000 |
Homocysteine | ||||
Baseline levels (median (IQR)) | 12.80 (10.17, 15.90) | 11.60 (8.10, 13.35) | 13.40 (10.70, 16.50) | <0.001 |
Homocysteinemia | 150 (48.1) | 20 (28.2) | 130 (53.9) | <0.001 |
MTHFR polymorphisms (%) †† | ||||
Any MTHFR polymorphism | 246 (81.5) | 47 (72.3) | 199 (84.0) | 0.050 |
A1298C (heterozygous) | 68 (22.5) | 20 (30.8) | 48 (20.3) | 0.103 |
C1298C (homozygous) | 20 (6.6) | 4 (6.2) | 16 (6.8) | 1.000 |
C677T (heterozygous) | 69 (22.8) | 13 (20.0) | 56 (23.6) | 0.652 |
T677T (homozygous) | 34 (11.3) | 3 (4.6) | 31 (13.1) | 0.091 |
A1298C/C677T | 57 (18.9) | 9 (13.8) | 48 (20.3) | 0.322 |
CBC‡‡ | ||||
WBC (median (IQR)) | 6.50 (5.30, 7.70) | 6.35 (5.15, 7.70) | 6.50 (5.40, 7.70) | 0.483 |
RBC (median (IQR)) | 4.60 (4.27, 4.89) | 4.78 (4.50, 4.98) | 4.51 (4.23, 4.85) | 0.001 |
Platelets (median (IQR)) | 232.00 (191.00, 282.00) | 251.50 (212.75, 302.50) | 228.00 (188.00, 275.00) | 0.006 |
Haemoglobin (median (IQR)) | 13.50 (12.40, 14.60) | 13.95 (12.62, 14.83) | 13.30 (12.30, 14.60) | 0.118 |
Haematocrit (median (IQR)) | 40.30 (37.50, 43.60) | 41.15 (37.75, 43.58) | 40.00 (37.50, 43.60) | 0.169 |
*BMI data missing for 78 (22 age<60, 56 age≥60) patients.
†Ethnicity data missing for two patients age≥60.
‡Smoking status missing for 86 (27 age<60, 59 age≥60) patients.
§Hypertension data missing for four (two age<60, two age≥60) patients.
¶Hypercholesterolaemia data missing for 62 (21 age<60, 41 age≥60) patients.
**Diabetes data missing for 54 (16 age<60, 38 age≥60) patients.
††MTHFR genotyping missing for 10 (6 age<60, 4 age≥60) patients.
‡‡CBC lab data missing for 39 (11 age<60, 28 age≥60) patients.
BMI, body mass index; BRVO, branch retinal vein occlusion; CBC, complete blood count; CRVO, central retinal vein occlusion; MTHFR, methylenetetrahydrofolate reductase; RVO, retinal vein occlusion.