Covariable | mRNFL | GC-IPL | ||||||
Total retinal thickness not included | Total retinal thickness included | Total retinal thickness not included | Total retinal thickness included | |||||
Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | |
Gender | ||||||||
Female | Reference | Reference | Reference | Reference | ||||
Male | −0.2 (−0.3 to −0.1) | <0.001 | −0.7 (−0.8 to −0.6) | <0.001 | 1.1 (0.9 to 1.3) | <0.001 | −0.3 (−0.4 to −0.2) | <0.001 |
Ancestral background | ||||||||
White | Reference | Reference | Reference | Reference | ||||
Asian | −0.9 (−1.2 to −0.6) | <0.001 | −0.2 (−0.4 to 0.1) | 0.27 | −1.9 (−2.5 to −1.4) | <0.001 | 0.1 (−0.3 to 0.5) | 0.58 |
Black | −1.5 (−2.3 to −0.6) | <0.001 | −0.2 (−1.0 to 0.5) | 0.56 | −2.4 (−3.9 to −1.0) | 0.001 | 0.9 (−0.1 to 1.9) | 0.09 |
Other | −0.6 (−0.8 to −0.3) | <0.001 | −0.1 (−0.4 to 0.2) | 0.52 | −0.3 (−0.8 to 0.2) | 0.20 | 0.9 (0.6 to 1.3) | <0.001 |
Prefer not to answer | 0.1 (−0.8 to 0.9) | 0.88 | 0.1 (−0.7 to 0.9) | 0.78 | 0.2 (−1.3 to 1.7) | 0.79 | 0.3 (−0.7 to 1.4) | 0.51 |
Alcohol intake | ||||||||
Never | Reference | Reference | Reference | Reference | ||||
Once or twice a week | 0.1 (−0.1 to 0.3) | 0.46 | 0.0 (−0.2 to 0.2) | 0.99 | 0.0 (−0.4 to 0.3) | 0.89 | −0.2 (−0.5 to 0.0) | 0.07 |
One to three times a month | 0.0 (−0.2 to 0.2) | 0.90 | 0.0 (−0.2 to 0.2) | 0.70 | 0.0 (−0.4 to 0.4) | 0.91 | −0.2 (−0.4 to 0.1) | 0.22 |
Prefer not to answer | −0.3 (−2.2 to 1.6) | 0.76 | −0.4 (−2.1 to 1.4) | 0.68 | −0.1 (−3.4 to 3.2) | 0.95 | −0.3 (−2.6 to 2.0) | 0.79 |
Special occasions only | 0.0 (−0.2 to 0.3) | 0.86 | −0.1 (−0.3 to 0.1) | 0.56 | −0.0 (−0.4 to 0.4) | 0.95 | −0.2 (−0.5 to 0.1) | 0.14 |
Three or four times a week | 0.0 (−0.2 to 0.2) | 0.76 | −0.1 (−0.3 to 0.0) | 0.13 | −0.3 (−0.6 to 0.1) | 0.13 | −0.6 (−0.8 to −0.3) | <0.001 |
Age (years) | 0.0 (0.0 to 0.0) | 0.77 | 0.0 (0.0 to 0.0) | <0.001 | −0.1 (−0.2 to −0.1) | <0.001 | −0.1 (−0.1 to −0.1) | <0.001 |
Glycated haemoglobin (only <6.5%) | −0.2 (−0.4 to −0.1) | 0.005 | −0.3 (−0.4 to −0.1) | <0.001 | 0.1 (−0.2 to 0.4) | 0.56 | 0.0 (−0.2 to 0.2) | 0.84 |
Diastolic blood pressure (mm Hg) | 0.0 (0.0 to 0.0) | 0.05 | 0.0 (0.0 to 0.0) | 0.09 | 0.0 (0.0 to 0.0) | 0.83 | 0.0 (0.0 to 0.0) | 0.23 |
Systolic blood pressure (mm Hg) | 0.0 (0.0 to 0.0) | <0.001 | 0.0 (0.0 to 0.0) | 0.004 | 0.0 (0.0 to 0.0) | 0.23 | 0.0 (0.0 to 0.0) | 0.92 |
Intraocular pressure (mm Hg) | 0.0 (0.0 to 0.0) | 0.42 | 0.0 (0.0 to 0.0) | 0.29 | 0.0 (0.0 to 0.0) | 0.36 | 0.0 (0.0 to 0.0) | 0.34 |
Visual acuity in logMAR | 0.8 (−1.2 to −0.4) | <0.001 | −0.4 (−0.8 to −0.1) | 0.02 | −1.9 (−2.6 to −1.2) | <0.001 | −1.0 (−1.5 to −0.5) | <0.001 |
Spherical power (dioptres) | 0.6 (0.6 to 0.6) | <0.001 | 0.2 (0.2 to 0.3) | <0.001 | ||||
Spherical equivalent (dioptres) | −0.3 (−0.3 to −0.3) | <0.001 | −0.5 (−0.5 to −0.4) | <0.001 | ||||
Total retinal thickness (μm) | 0.1 (0.1 to 0.1) | <0.001 | 0.3 (0.3 to 0.3) | <0.001 |
Variables for which the coefficient value changed from negative to positive or vice versa or statistical significance changed, for either RNFL or GC-IPL, are highlighted in bold.
GC-IPL, ganglion cell-inner plexiform layer; logMAR, logarithm of the minimum angle of resolution; mRNFL, macular retinal nerve fibre layer.