Eyes that lost at least five ETDRS letters
| (a) | M0 (n=678) | M1A (n=206) | M1S (n=356) | Overall (n=1240) |
| Baseline VA (mean; ETDRS letters) | ||||
| Mean (SD) | 72.7 (13.3) | 67.5 (14.2) | 69.3 (16.8) | 70.9 (14.7) |
| Median (min, max) | 76.0 (11.0, 94.0) | 70.0 (11.0, 89.0) | 76.0 (10.0, 94.0) | 76.0 (10.0, 94.0) |
| Change in VA from baseline (mean; ETDRS letters) | ||||
| Mean (SD) | −14.9 (14.2) | −13.7 (11.5) | −13.1 (11.2) | −14.2 (13.0) |
| Median (min, max) | −9.00 (−83.0, –5.00) | −9.00 (−63.0, –5.00) | −9.00 (−85.0, –5.00) | −9.00 (−85.0, –5.00) |
| Proportion >70 ETDRS letters in study eye | ||||
| No | 372 (54.9%) | 142 (68.9%) | 209 (58.7%) | 723 (58.3%) |
| Yes | 306 (45.1%) | 64 (31.1%) | 147 (41.3%) | 517 (41.7%) |
| Proportion <70 ETDRS letters in both eyes | ||||
| No | 504 (74.3%) | 128 (62.1%) | 240 (67.4%) | 872 (70.3%) |
| Yes | 174 (25.7%) | 78 (37.9%) | 116 (32.6%) | 368 (29.7%) |
| Proportion <35 ETDRS letters in study eye | ||||
| No | 564 (83.2%) | 164 (79.6%) | 293 (82.3%) | 1021 (82.3%) |
| Yes | 114 (16.8%) | 42 (20.4%) | 63 (17.7%) | 219 (17.7%) |
| Proportion <35 ETDRS letters in both eyes | ||||
| No | 641 (94.5%) | 194 (94.2%) | 342 (96.1%) | 1177 (94.9%) |
| Yes | 37 (5.5%) | 12 (5.8%) | 14 (3.9%) | 63 (5.1%) |
| Cataract surgery | ||||
| No | 677 (99.9%) | 206 (100%) | 356 (100%) | 1239 (99.9%) |
| Yes | 1 (0.1%) | 0 (0%) | 0 (0%) | 1 (0.1%) |
| DME | ||||
| No | 662 (97.6%) | 152 (73.8%) | 330 (92.7%) | 1144 (92.3%) |
| Yes | 16 (2.4%) | 54 (26.2%) | 26 (7.3%) | 96 (7.7%) |
| Vitrectomy | ||||
| No | 678 (100%) | 206 (100%) | 356 (100%) | 1240 (100%) |
| Yes | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| PRP | ||||
| No | 651 (96.0%) | 199 (96.6%) | 345 (96.9%) | 1195 (96.4%) |
| Yes | 27 (4.0%) | 7 (3.4%) | 11 (3.1%) | 45 (3.6%) |
| (b) | Baseline VA <70 (n=345) | Baseline VA >70 (n=895) | Overall (n=1240) |
| Baseline VA | |||
| Mean (SD) | 51.3 (12.3) | 78.3 (6.24) | 70.8 (14.7) |
| Median (min, max) | 55.0 (10.0, 69.0) | 76.0 (70.0, 94.0) | 76.0 (10.0, 94.0) |
| Post-event VA (mean; ETDRS letters) | |||
| Mean (SD) | 34.8 (18.2) | 65.1 (14.3) | 56.7 (20.6) |
| Median (min, max) | 35.0 (0, 61.0) | 70.0 (0, 89.0) | 61.0 (0, 89.0) |
| Post-event VA ≥70 ETDRS letters | |||
| VA <70 | 345 (100%) | 378 (42.2%) | 723 (58.3%) |
| VA >70 | 0 (0%) | 517 (57.8%) | 517 (41.7%) |
Visual acuity (VA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters shown for patients that lost five or more ETDRS letters at the time of visual loss event.
Specific aetiologies of the VA loss event was queried by identifying treatments carried out within 6 months of the event itself: cataract surgery for cataract; anti-VEGF or macular laser for diabetic macular oedema (DME); vitrectomy for vitreous haemorrhage; and panretinal photocoagulation (PRP) for reactivation of proliferative diabetic retinopathy. Cohort was considered overall and stratified by (a) macular status and (b) baseline visual acuity being <70 ETDRS letters or ≥70. Baseline (first recording of stable proliferative diabetes following panretinal photocoagulation) VA in ETDRS letters shown for overall cohort and substratified by macular status. Mean, median, SD, minimum and maximum values shown. Lens status, as well as, history of vitrectomy or DME is also shown.