Table 4

Synergy and antagonism with fluoroquinolone combination therapy

OrganismCombinationAntagonism (%)Indifferent (%)Additive (%)Synergy (%)
Staphylococcus aureusMeropenem+ciprofloxacin0207010
Meropenem+moxifloxacin060400
Moxifloxacin +
teicoplanin
040600
Ciprofloxacin +
teicoplanin
0405010
Pseudomonas aeruginosaMeropenem+ciprofloxacin0108010
Meropenem+moxifloxacin0503020
Gentamicin +ciprofloxacin101360
Gentamicin +moxifloxacin080020
  • In vitro results of a fluoroquinolone combined with a second antimicrobial against bacterial keratitis isolates. percentage of activity represents the percentage of isolates against which the respective antimicrobial combination provides a fractional inhibitory concentration that indicates an additive, indifferent, antagonistic or synergistic response.105