Multivariate regression analysis to explore associations with ‘poor’ visual acuity state at month 12
| Parameter | Estimate (OR) | 95% CI | p-value | |
| Intercept | 0.100 | (0.051 to 0.21) | ||
| Age (decades) | 1.450 | (1.40 to 1.50) | <0.001 | |
| Sex (male vs female) | 1.037 | (0.93 to 1.15) | 0.51 | |
| Independent living status (vs assisted) | 0.840 | (0.65 to 1.073) | 0.16 | |
| First-treated eye (vs second eye) | 0.890 | (0.79 to 0.99) | 0.04 | |
| Ocular comorbidity (present vs absent) | 0.950 | (0.84 to 1.079) | 0.44 | |
| Systemic comorbidity (present vs absent) | 0.980 | (0.87 to 1.094) | 0.69 | |
| Baseline visual acuity (0.1 LogMAR) | 1.660 | (1.61 to 1.7) | <0.001 | |
| Site (relative to A) | Site B | 0.440 | (0.32 to 0.6) | <0.001 |
| Site C | 0.610 | (0.43 to 0.86) | 0.005 | |
| Site D | 0.870 | (0.62 to 1.2) | 0.39 | |
| Site E | 0.740 | (0.56 to 0.97) | 0.03 | |
| Site F | 0.780 | (0.57 to 1.061) | 0.11 | |
| Site G | 0.840 | (0.64 to 1.096) | 0.2 | |
| Site H | 0.920 | (0.7 to 1.21) | 0.56 | |
| Site I | 1.210 | (0.91 to 1.61) | 0.18 | |
| Site J | 0.750 | (0.57 to 1.0) | 0.05 | |
| Site K | 1.100 | (0.8 to 1.51) | 0.55 | |
| Site L | 1.320 | (0.98 to 1.79) | 0.07 | |
| Site M | 0.890 | (0.66 to 1.21) | 0.46 | |
| IMD (quintiles relative to 1 (most deprived)) | IMD 2 | 1.079 | (0.91 to 1.28) | 0.39 |
| IMD 3 | 0.880 | (0.75 to 1.041) | 0.14 | |
| IMD 4 | 0.950 | (0.81 to 1.12) | 0.54 | |
| IMD 5 | 0.770 | (0.65 to 0.9) | 0.002 | |
| Number of injections (for each additional injection over 0) | 0.980 | (0.96 to 1.0053) | 0.14 | |
| Completion of loading phase of treatment (relative to fast completion) | Medium (9–10 weeks) | 1.120 | (0.98 to 1.28) | 0.09 |
| Slow (>10 weeks) | 1.260 | (1.066 to 1.48) | 0.007 | |
| Incomplete | 1.340 | (0.88 to 2.034) | 0.18 |