p Value | |||
Treatment | Time | Interaction | |
General evaluation | |||
Best corrected visual acuity (logMAR) | 0.96 | 0.15 | 0.33 |
Eyelid itching grade | 0.16 | 0.95 | 0.62 |
Eyelid pain grade | 0.33 | 0.77 | 0.38 |
Ocular surface evaluation | |||
Bulbar conjunctival hyperaemia | 0.15 | 0.18 | 0.92 |
Palpebral erythema | 0.94 | 0.14 | 0.35 |
Sodium fluorescein staining score (out of 55) | 0.12 | 0.62 | 0.16 |
Lissamine green staining score (out of 55) | 0.54 | 0.35 | 0.15 |
Lid wiper epitheliopathy grade | 0.27 | 0.79 | 0.24 |
Tear film evaluation | |||
Tear film lipid layer grade | 0.32 | 0.13 | 0.25 |
Tear evaporation rate (g/m2/h) | 0.31 | 0.15 | 0.47 |
Non-invasive tear film break-up time (s) | 0.67 | 0.74 | 0.51 |
Tear film osmolarity (mOsmol/kg) | 0.66 | 0.58 | 0.25 |
Tear meniscus height (mm) | 0.83 | 0.67 | 0.26 |
Impression cytology | |||
MMP-9 expression | 0.75 | 0.69 | 0.61 |
IL-6 expression | 0.23 | 0.13 | 0.10 |
MUC5AC expression | 0.39 | 0.55 | 0.31 |
IL-6, interleukin-6; MMP-9, matrix metalloproteinase-9; MUC5AC, mucin-5AC; SD standard deviation.