Relationship between retinal vascular parameters with glaucoma-associated outcomes
| Study and year | Study type | Sample size | Method of assessment | Outcome | Changes in parameters in association with glaucoma | ||||
| Arteriolar calibre | Venular calibre | Fractal dimension | Tortuosity | Branching angle | |||||
| Tham et al
87 (Singapore Malay Eye study) (2013) | Population-based, cross-sectional study | Healthy: 352 | SIVA | RNFL thickness | Reduced | Reduced | Reduced | Reduced | – |
| Kim et al 89 (2012) | Hospital-based, case-control study | Healthy: 48 NTG: 67 | Visupac | RNFL thickness | Reduced | Not significant | – | – | – |
| Koh et al
98 (Singapore Malay Eye Study) (2010) | Population-based, cross-sectional study | Healthy: 2641 | SIVA | Neuroretinal rim area | – | – | – | Reduced | – |
| Zheng et al
65 (Singapore Malay Eye Study) (2009) | Population-based, cross-sectional study | Healthy: 2599 Any glaucoma: 107 | IVAN | RNFL thickness | Reduced | Reduced | – | – | – |
| Cheung et al
88 (Sydney Childhood Eye Study) (2008) | Population-based, cross-sectional study | Healthy: 1204 | Optimate | RNFL thickness | Reduced | Reduced | – | – | – |
| Lim et al 90 (2009) | Hospital-based, cross-sectional study | Healthy: 104 | Optimate | RNFL thickness | Reduced | Reduced | – | – | – |
| CDR | Not significant | Reduced | – | – | – | ||||
| Samarawickrama et al
91 (Sydney Childhood Eye Study) (2003) | Population-based, cross-sectional study | Healthy: 2038 | Optimate | RNFL thickness | Reduced | Reduced | – | – | – |
| Hall et al
92 (2001) | Hospital-based case series | POAG: 64 | Manual | VFD | Reduced | Not significant | – | – | – |
| Jonas and Naumann86 (1989) | Hospital-based, case-control study | Healthy: 173 POAG: 281 | Manual | CDR | Reduced | Reduced | – | – | – |
| RNFL thickness | Reduced | Reduced | – | – | – | ||||
| VFD | Reduced | Reduced | – | – | – | ||||
CDR, cup–disc ratio; NTG, normal tension glaucoma; POAG, primary open-angle glaucoma; RNFL, retinal nerve fibre layer; VFD, visual field defect; SIVA, Singapore ‘I’ Vessel Assessment.