Associations between quantitative retinal vascular parameters with glaucoma in population-based and hospital-based cross-sectional studies
| Study and year | Study type | Sample size | Method of assessment | Changes in parameters in association with glaucoma | ||||
| Arteriolar calibre | Venular calibre | Fractal dimension | Tortuosity | Branching angle | ||||
| Ciancaglini et al
81 (2015) | Hospital-based cross-sectional study | N/A | Heidelberg Doppler flowmetry | – | – | Reduced | – | – |
| De Leon et al
72 (2015) | Hospital-based, cross-sectional study | Any glaucoma: 158 | IVAN | Reduced | Reduced | – | – | – |
| Gao et al
78 (Handan Eye Study) (2015) | Population-based cross-sectional study | Healthy: 5788 POAG: 54 PACG: 19 PACS: 731 PAC: 64 | Optimate | Reduced | Reduced | – | – | – |
| Yoo et al
79 (2015) | Hospital-based case-control study | Healthy: 60 HPG: 63 NTG: 82 | IVAN | Reduced | Not significant | – | – | – |
| Wu et al
82 (Singapore Malay Eye Study) (2013) | Population-based, cross-sectional study | Healthy: 2666 POAG: 87 OHT: 58 | SIVA | – | – | Reduced | Reduced | Reduced |
| Amerasinghe et al
76 (Singapore Malay Eye study) (2008) | Population-based, cross-sectional study | Healthy: 2892 POAG: 88 PACG: 5 NTG: 74 | IVAN | Reduced | Reduced | – | – | – |
| Wang et al
77 (Beijing Eye Study) (2007) | Population-based, cross-sectional study | Total: 2418 | Manual | Reduced | Not significant | – | – | – |
| Klein et al
80 (Beaver Dam Eye Study) (2004) | Population-based, cross-sectional study | Total: 4613 Any glaucoma: 199 | Optimate | Not significant | Not significant | – | – | – |
| Mitchell et al
75 (Blue Mountains Eye Study) (2004) | Population-based, cross-sectional study | Healthy: 3065 HPG: 38 NTG: 21 OHT: 163 | Optimate | Reduced | Reduced | – | – | – |
| Angelica et al
74 (2001) | Hospital-based, cross-sectional study | Total: 143 | HRT software 1.11, Interactive Means program | Not significant | – | – | – | – |
| Rankin et al
62 (1996) | Hospital-based, case-control study | Healthy: 7 POAG: 32 NTG: 48 OHT: 19 Suspects: 4 | Manual | Reduced | – | – | – | – |
| Rader et al
61 (1994) | Hospital-based, case-control study | Healthy: 206 Any glaucoma: 226 | Manual | Reduced | – | – | – | – |
| Jonas et al
60 (1989) | Hospital-based, cross-sectional study | Healthy: 173 POAG: 281 | Manual | Reduced | Reduced | – | – | – |
AVR, arteriovenous ratio; COAG, chronic open-angle glaucoma; HPG, high-pressure glaucoma; NTG, normal tension glaucoma; OHT, ocular hypertension; PAC, primary angle closure; PACG, primary angle closure glaucoma; PACS, primary angle closure suspect; POAG, primary open-angle glaucoma; SIVA, Singapore ‘I’ Vessel Assessment.