Table 1

Concentration (CFU/mL) and log10 decrease obtained in the time-kill studies of Kerasave and growth controls for each strain

Strain and incubation time (days)Mean concentration (CFU/mL)Log10 decrease
Growth controlsKerasaveGrowth controlsKerasaveP value*
Candida albicans ATCC 10231
 04.45×105±8.50×1044.45×105±8.50×104
 32.68×105±4.56×1044.83×102±9.65×1010.18±0.102.97±0.11<0.001
 142.93×105±6.02×1040.18×100±0.12×1000.19±0.115.52±0.08<0.001
Fusarium solani DSM-N°1164
 03.15×105±9.57×1033.15×105±9.57×103
 32.35×105±2.09×1046.15×104±3.06×1030.13±0.040.67±0.030.004
 142.12×105±2.65×1041.62×104±1.07×1030.19±0.051.25±0.030.006
Aspergillus brasiliensis ATCC 16404
 04.45×105±6.58×1044.45×105±6.58×104
 31.58×106±3.89×1052.90×105±6.41×104−0.44±0.130.30±0.14<0.001
 142.03×107±3.80×1062.29×107±5.07×106−1.64±0.10−1.62±0.110.640
Staphylococcus aureus ATCC 6538
 04.86×105±5.86×1044.86×105±5.86×104
 38.03×105±1.50×1053.61×103±7.55×102−0.13±0.122.27±0.11<0.001
 142.27×106±4.99×1051.84×102±2.39×101−0.60±0.113.39±0.07<0.001
Bacillus subtilis spizizenii ATCC 6633
 02.13×106±2.93×1052.13×106±2.93×105
 31.44×107±4.95×1061.01×106±1.22×105−0.51±0.140.25±0.08<0.001
 143.38×106±4.60×1051.19×106±1.30×105−0.21±0.090.18±0.080.001
Enterococcus faecalis ATCC 29212
 04.07×106±4.04×1054.07×106±4.04×105
 31.93×107±1.04×1063.11×104±4.72×103−0.76±0.062.11±0.09<0.001
 143.25×1010±5.78×1091.20×103±1.78×102−3.91±0.113.53±0.08<0.001
Pseudomonas aeruginosa ATCC 9027
 02.10×106±3.11×1052.10×106±3.11×105
 31.11×106±2.88×1051.73×102±3.20×1010.47±0.144.15±0.10<0.001
 143.51×106±7.97×1059.78×10−1±1.78×10−1−0.09±0.126.20±0.08<0.001
Klebsiella pneumoniae ATCC 10031
 02.72×105±2.82×1042.72×105±2.82×104
 32.77×105±3.70×1040.00×100±0.00×100−0.03±0.065.37±0.04<0.001
 141.83×105±3.64×1040.00×100±0.00×1000.19±0.075.37±0.04<0.001
Enterobacter cloacae ATCC 35030
 03.92×105±5.24×1043.92×105±5.24×104
 32.35×105±3.23×1043.95×103±1.76×1030.16±0.082.67±0.27<0.001
 148.20×108±5.87×1070.00×100±0.00×100−3.42±0.065.49±0.05<0.001
  • Data are expressed as mean±SEM.

  • *P value corresponds to Mann-Whitney U test on the log10 decrease values between Kerasave and growth controls.

  • ATCC, American Type Culture Collection; CFU, colony forming unit; DSM, Deutsche Sammlung von Mikroorganismen.