Baseline characteristics of eyes with and without OCT features in Best vitelliform macular dystrophy
Pre-VL | Solid VL | VL with SRF | Atrophy | Pillar | FCE | IRF | ||
Number of eyes with feature present | 18 | 8 | 58 | 7 | 23 | 19 | 14 | |
Percentage of total (%) | 18.9 | 8.4 | 61.1 | 7.4 | 24.2 | 20.0 | 14.7 | |
LogMAR VA (mean, median, range) | Feature present | 0.05, 0.0, −0.12 to 0.54 | 0.27, 0.18, 0.10 to 0.90 | 0.34, 0.30, –0.12 to 1.00 | 0.72, 0.80, 0.54 to 0.88 | 0.42, 0.3, −0.12 to 1.00 | 0.48, 0.48, 0.00 to 1.00 | 0.5, 0.51, 0.1 to 1.00 |
Feature absent | 0.37, 0.30, –0.12 to 1.00 | 0.31, 0.30, –0.12 to 1.00 | 0.26, 0.18, –0.12 to 0.90 | 0.27, 0.30, −0.12 to 0.90 | 0.27, 0.18, –0.12 to 1.00 | 0.28, 0.20, –0.12 to 1.00 | 0.28, 0.20, –0.12 to 1.00 | |
P value | 0.001* | 0.34 | 0.19 | 0.001* | 0.04* | 0.01* | 0.003* | |
% Eyes with VA ≥20/50* | Feature present | 94.4 | 88.9 | 60.7 | 14.3 | 52.2 | 47.4 | 28.6 |
Feature absent | 55.8 | 60.5 | 67.6 | 67.1 | 66.7 | 67.1 | 73.1 | |
Age (years) (mean, median, range) | Feature present | 41.3, 35.0, 16 to 87 | 30.4, 27.0, 6 to 68 | 37.5, 34.0, 4 to 84 | 49.0, 57.0, 42 to 68 | 32.8, 31.0, 7 to 63 | 34.0, 32.0, 13 to 68 | 35.6, 28.5, 12 to 60 |
Feature absent | 38.3, 36.0, 4 to 84 | 39.5, 36.0, 4 to 87 | 41.0, 38.0, 6 to 87 | 38.1, 34.0, 4 to 87 | 40.8, 39.5, 4 to 87 | 40.1, 37.5, 4 to 87 | 39.5, 37.0, 4 to 87 | |
P value | 0.31 | 0.15 | 0.22 | 0.057 | 0.04* | 0.09 | 0.24 | |
CST (µm) (mean, median, range) | Feature present | 295.6, 289, 242 to 337 | 414.8, 397.0, 233 to 570 | 366.6, 342.0, 177 to 627 | 227.3, 210.0, 177 to 352 | 403.0, 391.0, 245 to 627 | 347.2, 355.0, 73 to 627 | 363.6, 363.5, 73 to 624 |
Feature absent | 358.7, 339.0, 73 to 627 | 340.5, 316, 73 to 627 | 315.6, 299, 73 to 570 | 356.2, 329.5, 73 to 627 | 328.8, 312.5, 73 to 570 | 346.6, 316.0, 186 to 624 | 343.8, 316.0, 177 to 627 | |
P value | 0.001* | 0.16 | 0.018* | 0.0003* | 0.003* | 0.49 | 0.32 |
*P value <0.05 considered statistically significant.
CST, central subfield thickness; FCE, focal choroidal excavation; IRF, intraretinal fluid; OCT, optical coherence tomography; SRF, subretinal fluid; VA, visual acuity; VL, vitelliform.