Utah Project on Exfoliation Syndrome (UPEXS) comorbid phenotypes and XFS, summary of evidence
| Risk of XFS in comorbid cohort vs comorbid controls | Risk of comorbid condition in XFS vs XFS controls | |
| Atrial fibrillation (AFib) | 1.2x | 1.2x |
| With history of hypertension | ↔ | ↔ |
| Without history of hypertension | 1.7x | 1.5x |
| Chronic obstructive pulmonary disease (COPD) | ↔ | 1.4x |
| With tobacco use history | ↔ | 2.2x |
| Inguinal hernia (IH) | 2.3x | ─ |
| Direct IH | 1.6x | ─ |
| Indirect IH | 12.0x | ─ |
| Obstructive sleep apnoea (OSA) | 1.3x | ↔ |
| With history of hypertension | 2.7x | 1.5x |
| Pelvic organ prolapse (POP) | 1.6x | ─ |
| Incident XFS (longitudinal study) | 1.5x | ─ |
An 'x' indicates an x-fold increased risk. A dash (–) indicates not investigated.
An ↔ indicates no association (95% CI-lower ≥0.8, 95% CI-upper ≤1.2).
Bold, p≤0.05; unbold, 0.05<p≤0.10; unbold grey font, p>0.10.
XFS, exfoliation syndrome.