Table 4

Univariable and multivariable logistic regression analyses investigating factors predictive of functional and anatomical responses

VariablesUnivariableMultivariable
B95% CIP valueB95% CIP value
≥5 ETDRS letters improvement
Baseline BCVA
(ETDRS letters)
−0.041−0.066 to 0.0160.001−0.032−0.063 to 0.0010.042
Baseline CMT
(μm)
0.0030.0003 to 0.0050.030−0.0004−0.003 to 0.0040.819
No of Injections0.148−0.012 to 0.3100.0710.086−0.095 to 0.2670.352
nAMD vs DMO (DMO=ref)1.2230.329 to 2.1170.0070.647−0.428 to 1.7240.238
RVO vs DMO
(DMO=ref)
1.5810.540 to 2.6220.0031.1890.067 to 2.3110.038
nAMD vs RVO
(RVO=ref)
−0.357−1.325 to 0.6090.469−0.542−1.669 to 0.5850.346
Lens status
(phakic=ref)
−0.684−1.430 to 0.0610.072
Laterality of eye (right=ref)−0.594−1.330 to 0.14220.114
Age (years)0.027−0.009 to 0.0630.1400.019−0.025 to 0.0640.396
Smoker (yes=ref)0.121−0.625 to 0.8670.750
Hypertension
(yes=ref)
0.211−0.637 to 1.0610.625
Hyperlipidaemia
(yes=ref)
0.562−0.195 to 1.3200.146
Sex (male=ref)0.289−0.441 to 1.0190.438
≥15 ETDRS letters improvement
Baseline BCVA
(ETDRS letters)
−0.054−0.081 to 0.028<0.001−0.065−0.101 to 0.029<0.001
Baseline CMT
(μm)
0.002−0.0001 to 0.0050.041−0.002−0.006 to 0.0010.235
No of Injections0.798−0.098 to 0.2580.3810.013−0.205 to 0.2320.903
nAMD vs DMO (DMO=ref)*2.1080.564 to 3.6520.0071.673−0.102 to 3.4500.065
RVO vs DMO
(DMO=ref)*
2.5930.996 to 4.1910.0012.5620.818 to 4.3050.004
nAMD vs RVO
(RVO=ref)*
−0.485−1.420 to 0.4490.309−0.888−2.111 to 0.3340.154
Lens status (phakic=ref)−0.555−1.419 to 0.3090.208
Laterality of eye (right=ref)−0.465−1.294 to 0.3640.272
Age (years)0.015−0.025 to 0.0560.453−0.003−0.057 to 0.0500.899
Smoker (yes=ref)0.148−0.686 to 0.9830.720
Hypertension
(yes=ref)
0.073−0.869 to 1.0160.878
Hyperlipidaemia
(yes=ref)
0.688−0.143 to 1.5210.105
Sex (male=ref)−0.075−0.897 to 0.7460.858
≥10% CMT reduction
Baseline BCVA
(ETDRS letters)
−0.025−0.049 to 0.0020.0290.013−0.023 to 0.0500.482
Baseline CMT
(μm)
0.0160.009 to 0.023<0.0010.0170.009, 0.026<0.001
No of Injections−0.010−0.170 to 0.1490.899−0.082−0.292 to 0.1270.441
nAMD vs DMO (DMO=ref)−0.452−1.327 to 0.4210.310−0.162−1.378 to 1.0530.793
RVO vs DMO
(DMO=ref)
0.576−0.505 to 1.6580.297−0.081−1.454 to 1.2910.908
nAMD vs RVO
(RVO=ref)
−1.02−2.041 to 0.0160.046−0.081−1.433 to 1.2710.906
Lens status
(phakic=ref)
0.001−0.760 to 0.7630.997
Laterality of eye (right=ref)0.100−0.651 to 0.8520.793
Age (years)−0.029−0.067 to 0.0080.132−0.008−0.060 to 0.0440.766
Smoker (yes=ref)0.296−0.481 to 1.0750.455
Hypertension
(yes=ref)
−0.641−1.494 to 0.2120.141
Hyperlipidaemia
(yes=ref)
−0.473−1.239 to 0.2920.226
Sex (male=ref)−0.328−1.086 to 0.4290.396
  • Significant p values are bolded.

  • *Firth-logistics; multivariable=adjusted for baseline BCVA, baseline CMT, injection number, age and disease type.

  • BCVA, best-corrected visual acuity; CMT, central macular thickness; DMO, diabetic macular oedema; ETDRS, early treatment diabetic retinopathy study; nAMD, neovascular age-related macular degeneration; RVO, retinal vein occlusion.