Multivariable logistic regression analysis of effect of higher oxygen saturation targets on ROP outcomes, controlling for other possible confounding predictors
| Outcome intercept | Any ROP (n=188/627) | ROP that progressed (n=49/188) | ROP requiring treatment (n=63/188) | IVH (n=201/622) | ||||
| P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | |
| Higher oxygen (epoch 2) (n=344/651) | 0.0012 | 2.2 (1.36 to 3.44) | 0.009 | 3.0 (1.31 to 6.81) | 0.22 | 0.65 (0.32 to 1.29) | <0.0001 | 6.75 (4.13 to 11.03) |
| Sepsis present (n=368/620) | 0.0005 | 2.5 (1.48 to 4.2) | 0.38 | 0.64 (0.24 to 1.70) | 0.05 | 2.62 (0.9 to 6.9) | 0.23 | 1.36 (0.82 to 2.26) |
| Surfactant (n=279/622) | 0.38 | 0.79 (0.47 to 1.33) | 0.96 | 1.02 (0.38 to 2.72) | 0.72 | 0.88 (0.42 to 1.83) | 0.98 | 0.99 (0.59 to 1.66) |
| Steroid (n=478/616) | 0.78 | 1.07 (0.66 to 1.75) | 0.41 | 0.70 (0.29 to 1.65) | 0.58 | 1.24 (0.58 to 2.63) | 0.65 | 1.12 (0.69 to 1.79) |
| IPPV ≥7 days (n=207/651) | <0.0001 | 5.01 (2.46 to 10.53) | 0.25 | 2.89 (0.47 to 7.71) | 0.0017 | 7.9* (2.17 to 28.82) | 0.0017 | 3.34 (1.57 to 7.08) |
| Transfusion (n=317/623) | 0.08 | 1.60 (0.95 to 2.70) | 0.026 | 4.98* (1.22 to 20.39) | 0.42 | 1.47 (0.57 to 3.76) | 0.0064 | 2.09 (1.23 to 3.55) |
| Heart disease (n=279/622) | 0.029 | 1.65 (1.05 to 2.57) | 0.92 | 0.95 (0.38 to 2.35) | 0.29 | 1.46 (0.71 to 2.97) | 0.005 | 1.91 (0.82 to 2.26) |
| Birth weight >1000 g (n=417/626) | <0.0001 | 0.09 (0.05 to 0.16) | NA | NA | <0.0001 | 0.03 (0.01 to 0.07) | NA | NA |
| Gestation >28 weeks (n=319/626) | <0.0001 | 0.08 (0.05 to 0.12) | NA | NA | <0.001 | 0.09 (0.05 to 0.16) | NA | NA |
*This OR should be interpreted with caution since the 95% CI is too wide.
IPPV, invasive positive pressure ventilation; IVH, intraventricular haemorrhage; NA, not available/not analysed; ROP, retinopathy of prematurity.