Table 3

Comparison of the two epochs from this study with SUPPORT, BOOST trials and COT cohorts to highlight differences in infant gestation and birth weight studied, oxygen targets and outcome measures to stress importance of generating outcomes of effect of oxygen changes according to local populations and screening criteria (for the clinical trials shown here, only p values that were significant are given in the table)

CohortsThis study
Outcomes at discharge from ROP screening
SUPPORT14
Outcomes at discharge from NICU
BOOST I15
Outcomes assessed at 12 months corrected age
BOOST II4
Outcomes assessed at 24 months corrected age
COT6
Outcomes assessed at 18 months corrected age
Epoch 1
Lower oxygen
(88–92%)
Epoch 2
Higher oxygen
(90–95%
(99%))
P valueLower oxygen
(85–89%)
Higher oxygen
(91–95%)
Lower oxygen
(91–94%)
Higher oxygen
(95–98%)
Lower oxygen (85–89%)Higher oxygen
(91–95%)
Lower oxygen
(85–89%)
Higher oxygen
(91–95%)
Number (n)30734465466217818012241224578569
Gestation
(weeks)
29.1 (2)29.3 (2)0.2426 (1)26 (1)26.6 (1)26.5 (1)26.0 (1.2)26 (1.2)25.6 (1)25.6 (1)
Birth weight
(g)
1115.8
(309.5)
1167
(338.2)
0.05836 (193)825 (193)918 (229)916 (231)826 (184)837 (189)827 (190)844 (199)
Mortality4.23%0%0.000119.9%16.2%
(p=0.04)
3%5%23.1%15.9% (p=0.002)16.6%15.3%
Sepsis (including NEC)78.5%41.2%<0.000136.5%35.6%NRNR10.4%8% (p=0.04)12.3%9.3%
Intraventricular haemorrhage (except for COT which included other brain injuries)20.19%43.75%0.000127.4%23.6%NRNR11.63%10.4%20.6%23.1%
ROP cases detected30.6%29.4%0.7328.3%32.1%84%88%NRNR64.7%62.6%
ROP cases requiring treatment14.33%5.93%0.00058.6%18%
(p<0.001)
11%6%10.6%13.5%
(p=0.04)
12.8%13.1%
Surfactant given46.2%58.3%0.002581.3%84.5%78%76%NRNR89.4%84.7%
(p=0.02)
Steroid given81%74.5%0.0696.8%95.6%83%83%NRNR88.2%90.0%
Heart disease52.%40.0%0.000348%
(PDA)
50%
(PDA)
53%
(PDA)
51%
(PDA)
48%
(PDA)
45%
(PDA)
NRNR
  • *Statistically significant.

  • APROP, aggressive posterior retinopathy of prematurity; IPPV, invasive positive pressure ventilation; NEC, necrotising enterocolitis; NICU, neonatal intensive care unit; NR, not reported in the paper; PDA, patent ductus arteriosus; PE, pre-ecclampsia; ROP, retinopathy of prematurity.