Baseline data†
| Group L1 | Group S1 | Group L2 | Group S2 | Total | |
| Low dose, monthly schedule | Standard dose, monthly schedule | Low dose, bimonthly schedule | Standard dose, bimonthly schedule | ||
| (n=204) | (n=203) | (n=203) | (n=202) | (n=812) | |
| Age at enrolment (years) | |||||
| Mean (SD) | 79 (7.5) | 80 (7.6) | 80 (7.4) | 81 (7.0) | 80 (7.4) |
| Min, max | 54–95 | 54–98 | 60–99 | 62–101 | 54–101 |
| Gender | |||||
| Male | 84 (41) | 85 (42) | 85 (42) | 93 (46) | 347 (43) |
| Female | 120 (59) | 118 (58) | 118 (58) | 109 (54) | 465 (57) |
| Smoking history | |||||
| Current smoker | 29 (14) | 27 (13) | 21 (10) | 25 (12) | 102 (13) |
| Ex-smoker | 108 (53) | 104 (51) | 103 (51) | 103 (51) | 418 (51) |
| Never smoked | 67 (33) | 72 (35) | 79 (39) | 74 (37) | 292 (36) |
| Considered primary eye | |||||
| Right | 104 (51) | 108 (53) | 95 (47) | 101 (50) | 408 (50) |
| Left | 100 (49) | 95 (47) | 108 (53) | 101 (50) | 404 (50) |
| Visual acuity at baseline (visit A) | |||||
| Primary eye mean (SD) | 56.1 (15.1) | 56.2 (14.0) | 56.7 (13.3) | 56.0 (13.9) | 56.3 (14.1) |
| Median (IQR) | 60 (48–67) | 59 (50–67) | 60 (49–67) | 59 (48–67) | 59 (48–67) |
| Min, max | 20–83 | 8–80 | 25–89 | 16–78 | 8–89 |
| n | 200 | 199 | 201 | 199 | 799 |
| Fellow eye mean (SD) | 60.0 (12.7) | 59.1 (14.9) | 62.0 (12.2) | 62.0 (10.1) | 60.9 (12.5) |
| Median (IQR) | 64.5 (56–67.5) | 63 (50–69) | 62 (53–72) | 62.5 (57–69) | 63 (55–69) |
| Min. max | 27–85 | 21–79 | 36–83 | 28–78 | 21–85 |
| n | 32 | 25 | 22 | 26 | 105 |
| Primary eye distance visual acuity* | |||||
| Mean (SD) | 58.7 (15.9) | 58.3 (14.4) | 59.4 (12.8) | 58.3 (14.3) | 58.7 (14.4) |
| Median (IQR) | 64 (49.5–70) | 60 (51–70) | 62 (50–69) | 63 (50–70) | 63 (50–70) |
| Min, max | 14–83 | 14–83 | 23–86 | 18–81 | 9–86 |
| n | 200 | 199 | 201 | 199 | 799 |
*Mean of visual acuity at loading dose visit A, B and C.
†All data are n (%) unless otherwise indicated.