Table 2

Comparison between SARS-CoV-2 and other human coronaviruses (HCoV)

HCoVGlobal mortality rateGenomic sizeTarget host receptorKnown ocular manifestations
SARS-CoV9.6% to 11%27.9 kbACE2Nil known
MERS-CoV37.1%30.1 kbDPP4Nil known
SARS-CoV-22.9%29.9 kbACE2Conjunctival hyperaemia chemosis and secretions
Epiphora
Eyelid oedema
Tarsal pseudomembranous
Eye discomfort
Follicular and haemorrhagic conjunctivitis
Photophobia
Superficial punctate keratitis
Corneal epithelial defect
Subepithelial infiltrates
Pseudodendrite
Dry eyes
Asymptomatic retinal lesions
Cotton wool spots
Retinal microhaemorrhages
  • CoV, coronavirus; MERS, Middle East respiratory syndrome; SARS, severe acute respiratory syndrome.