Table 2

Expression levels in ARPE-19 Treated cells with CPFX and TETRA compared with vehicle-treated controls

SymbolTreated cells with CPFX versus vehicle-control*
P value, fold
Treated cells with TETRA versus vehicle-control*
P value, fold
Apoptosis-regulator genes
 BAX0.0020.04
1.977±0.031.465±0.09
 BCL2-L130.0140.026
1.41±0.021.14±0.03
 BCl20.0610.024
1.76±0.042.82±0.56
 CASP30.2460.250
1.39±0.091.25±0.30
 CASP70.0030.002
1.71±0.021.71±0.02
 CASP90.0130.007
2.13±0.191.43±0.03
Antioxidant enzymes related genes
 SOD20.0140.048
1.26±0.061.27±0.07
 SOD30.240.041
0.80±0.050.41±0.05
 NOX40.0310.045
0.84±0.060.37±0.02
 GPX30.0180.249
1.24±0.060.69±0.01
Inflammatory pathway genes
 IL-60.0480.001
1.31±0.035.11±0.16
 IL-1β0.860.023
0.31±0.052.29±0.19
 IL-330.0470.011
0.34±0.040.11±0.008
 TGF-α10.2110.014
0.67±0.060.41±0.02
 TGF-β10.0610.043
1.003±0.080.54±0.02
 TGF-β20.4100.177
0.62±0.040.74±0.07
  • Fold values greater than 1 indicate upregulation of the gene.

  • Fold values less than 1 indicate downregulation of the gene.

  • *Are assigned a value of 1.

  • ARPE-19, human retinal pigment epithelial cells; CPFX, ciprofloxacin; IL-6, interleukin-6; TETRA, tetracycline; TGF-β1, transforming growth factor-β1.