Table 1

Information of the genes related to apoptotic, inflammatory and antioxidant pathways

SymbolGene nameGenBank
accession no
Function
BAXBCL2-associated XNM_001291429This gene encodes a mitochondrially localised protein with conserved B-cell lymphoma two homology motifs. Overexpression of the encoded protein induces apoptosis.
NM_001291428
NM_001291430
NM_001291431
NM_004324
NM_138761
NM_138763
NM_138764
BCL2-L13BCL2 like 13NM_015367Encodes a mitochondrially localised protein, apoptosis inducer.
NM_001270729
NM_001270731
NM_001270732
NM_001270734
NM_001270735
BCL2BCL2 apoptosis regulatorNM_000633Encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells (eg, lymphocytes).
CASP-3Caspase 3, apoptosis-related cysteine peptidaseNM_004346Encodes protein as a cysteine-aspartic acid protease that plays a central role in the execution phase of cell apoptosis.
NM_032991
CASP-7Caspase 7, apoptosis-related cysteine peptidaseNM_145248,This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis.
XM_006725153.
XM_006725154,
XM_005268295,
XM_006725155,
XM_005268294,
XM_006719962
CASP-9Caspase 9, apoptosis-related cysteine peptidaseNM_0 01 229
NM_032996
Encodes a member of the cysteine aspartic acid protease (caspase) family, which is involved in the execution phase of cell apoptosis.
IL-1βIL-1, betaNM_000576Produced by activated macrophages, IL-1 stimulates thymocyte proliferation. The protein encoded by this gene is a member of the IL-1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes and haematopoiesis
IL-6IL-6NM_000600This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections.
IL-33IL-33NM_033439The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells.
NM_001199640
NM_001127180
TGF-αTGF alphaNM_003236This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signalling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand.
NM_001099691
TGF-β1TGF beta-1-likeNM_003238This gene is a polypeptide member of the TGF beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis.
TGF-β2TGF beta 2NM_001135599This gene encodes a secreted ligand of the TGF-beta superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.
SOD2Superoxide dismutase 2NM_000636This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a tetrameter and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen.
SOD3Superoxide dismutase 3NM-003102This gene encodes a member of the SOD protein family, which catalyses the conversion of superoxide radicals into hydrogen peroxide and oxygen, effective in protection of the brain, lungs and other tissues from oxidative stress.
GPX3Glutathione peroxidase 3NM_002084The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyse the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity.
SOD2Superoxide dismutase 2NM_000636This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen.
SOD3Superoxide dismutase 3NM-003102This gene encodes a member of the SOD protein family, which catalyses the conversion of superoxide radicals into hydrogen peroxide and oxygen, effective in protection of the brain, lungs and other tissues from oxidative stress.
GPX3Glutathione peroxidase 3NM_002084The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyse the reduction of organic H2O2 by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity.
NOX4NADPH oxidase 4NM_001143836This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localised to non-phagocytic cells where it acts as an oxygen sensor and catalyses the reduction of molecular oxygen to various reactive oxygen species.
NM_016931
NM_001143837
NR_026571
NM_001291926
NM_001300995
XM_006718848
NM_001291927
XM_006718852
XM_006718853
NM_001291929
XM_006718849
  • IL-1, interleukin-1; SOD, superoxide dismutase; TGF, transforming growth factor.