Information of the genes related to apoptotic, inflammatory and antioxidant pathways
| Symbol | Gene name | GenBank accession no | Function |
| BAX | BCL2-associated X | NM_001291429 | This gene encodes a mitochondrially localised protein with conserved B-cell lymphoma two homology motifs. Overexpression of the encoded protein induces apoptosis. |
| NM_001291428 | |||
| NM_001291430 | |||
| NM_001291431 | |||
| NM_004324 | |||
| NM_138761 | |||
| NM_138763 | |||
| NM_138764 | |||
| BCL2-L13 | BCL2 like 13 | NM_015367 | Encodes a mitochondrially localised protein, apoptosis inducer. |
| NM_001270729 | |||
| NM_001270731 | |||
| NM_001270732 | |||
| NM_001270734 | |||
| NM_001270735 | |||
| BCL2 | BCL2 apoptosis regulator | NM_000633 | Encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells (eg, lymphocytes). |
| CASP-3 | Caspase 3, apoptosis-related cysteine peptidase | NM_004346 | Encodes protein as a cysteine-aspartic acid protease that plays a central role in the execution phase of cell apoptosis. |
| NM_032991 | |||
| CASP-7 | Caspase 7, apoptosis-related cysteine peptidase | NM_145248, | This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. |
| XM_006725153. | |||
| XM_006725154, | |||
| XM_005268295, | |||
| XM_006725155, | |||
| XM_005268294, | |||
| XM_006719962 | |||
| CASP-9 | Caspase 9, apoptosis-related cysteine peptidase | NM_0 01 229 NM_032996 | Encodes a member of the cysteine aspartic acid protease (caspase) family, which is involved in the execution phase of cell apoptosis. |
| IL-1β | IL-1, beta | NM_000576 | Produced by activated macrophages, IL-1 stimulates thymocyte proliferation. The protein encoded by this gene is a member of the IL-1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes and haematopoiesis |
| IL-6 | IL-6 | NM_000600 | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. |
| IL-33 | IL-33 | NM_033439 | The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. |
| NM_001199640 | |||
| NM_001127180 | |||
| TGF-α | TGF alpha | NM_003236 | This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signalling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. |
| NM_001099691 | |||
| TGF-β1 | TGF beta-1-like | NM_003238 | This gene is a polypeptide member of the TGF beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. |
| TGF-β2 | TGF beta 2 | NM_001135599 | This gene encodes a secreted ligand of the TGF-beta superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. |
| SOD2 | Superoxide dismutase 2 | NM_000636 | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a tetrameter and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. |
| SOD3 | Superoxide dismutase 3 | NM-003102 | This gene encodes a member of the SOD protein family, which catalyses the conversion of superoxide radicals into hydrogen peroxide and oxygen, effective in protection of the brain, lungs and other tissues from oxidative stress. |
| GPX3 | Glutathione peroxidase 3 | NM_002084 | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyse the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. |
| SOD2 | Superoxide dismutase 2 | NM_000636 | This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. |
| SOD3 | Superoxide dismutase 3 | NM-003102 | This gene encodes a member of the SOD protein family, which catalyses the conversion of superoxide radicals into hydrogen peroxide and oxygen, effective in protection of the brain, lungs and other tissues from oxidative stress. |
| GPX3 | Glutathione peroxidase 3 | NM_002084 | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyse the reduction of organic H2O2 by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. |
| NOX4 | NADPH oxidase 4 | NM_001143836 | This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localised to non-phagocytic cells where it acts as an oxygen sensor and catalyses the reduction of molecular oxygen to various reactive oxygen species. |
| NM_016931 | |||
| NM_001143837 | |||
| NR_026571 | |||
| NM_001291926 | |||
| NM_001300995 | |||
| XM_006718848 | |||
| NM_001291927 | |||
| XM_006718852 | |||
| XM_006718853 | |||
| NM_001291929 | |||
| XM_006718849 |
IL-1, interleukin-1; SOD, superoxide dismutase; TGF, transforming growth factor.