FAS population (n=513) | Regular cohort (n=102) | Irregular cohort with treatment initiation (n=266) | Irregular cohort without treatment initiation (n=60) | |
Age, years* | 79.6 (7.9) | 79.2 (7.6) | 79.2 (7.7) | 81.3 (7.1) |
Male, n (%) | 199 (38.8) | 41 (40.2) | 103 (38.7) | 19 (31.7) |
Neovascular AMD diagnosis, n (%) | ||||
One eye | 513 (100.0) | 102 (100.0) | 266 (100.0) | 60 (100.0) |
Duration of neovascular AMD, months† | 0.1 | 0.1 | 0.2 | 0.1 |
Comorbidities, n (%) | ||||
Diabetes mellitus | 42 (8.2) | 7 (6.9) | 21 (7.9) | 8 (13.3) |
Hypertension | 190 (37.0) | 38 (37.3) | 106 (39.8) | 19 (31.7) |
Cardiovascular disease | 85 (16.6) | 14 (13.7) | 47 (17.7) | 8 (13.3) |
CRT, µm (n=458) | 399.4 (141.9) | 403.9 (147.8) | 402.9 (140.1) | 380.4 (148.4) |
CNV on FA, n (%) (n=386) | ||||
Minimally classic | 34 (8.8) | 11 (12.5) | 14 (7.0) | 6 (13.6) |
Predominantly classic | 76 (19.7) | 22 (25.0) | 29 (14.6) | 10 (22.7) |
Purely occult | 130 (33.7) | 34 (38.6) | 62 (31.2) | 15 (34.1) |
Retinal choroidal anastomosis | 43 (11.1) | 6 (6.8) | 25 (12.6) | 7 (15.9) |
RPE detachment | 31 (8.0) | 5 (5.7) | 23 (11.6) | 1 (2.3) |
Extrafoveal | 3 (0.8) | 1 (1.1) | 2 (1.0) | 0 |
Subfoveal | 20 (5.2) | 2 (2.3) | 13 (6.5) | 1 (2.3) |
Presence of RPE tear, n (%) (n=386) | 7 (1.8) | 0 | 4 (2.0) | 2 (4.5) |
Outcomes on SD OCT, n (%) (n=489) | ||||
Presence of subretinal fluid | 403 (82.4) | 80 (81.6) | 213 (83.5) | 39 (69.6) |
Presence of intraretinal fluid | 309 (63.2) | 58 (59.2) | 159 (62.4) | 38 (67.9) |
Presence of sub-RPE fluid | 241 (49.3) | 47 (48.0) | 134 (52.5) | 28 (50.0) |
Pigment epithelium detachment | 309 (63.2) | 52 (53.1) | 175 (68.6) | 31 (55.4) |
Suspicion for RAP | 59 (12.1) | 13 (13.3) | 31 (12.2) | 7 (12.5) |
PCV | 31 (6.3) | 6 (6.1) | 14 (5.5) | 5 (8.9) |
*Mean (SD).
†Median.
AMD, age-related macular degeneration; CNV, choroidal neovascularisation; CRT, central retinal thickness; FA, fluorescein angiography; FAS, full analysis set; PCV, polypoidal choroidal vasculopathy; RAP, retinal angiomatous proliferation; RPE, retinal pigment epithelium; SD OCT, spectral domain optical coherence tomography.