RT Journal Article
SR Electronic
T1 Prevalence and factors associated with optic disc grey crescent in the Primary Open-Angle African Ancestry Glaucoma Genetics (POAAGG) Study
JF BMJ Open Ophthalmology
JO BMJ Open Ophth
FD BMJ Publishing Group Ltd
SP e001183
DO 10.1136/bmjophth-2022-001183
VO 8
IS 1
A1 Ebenezer Daniel
A1 Jinpeng Gao
A1 Maureen G Maguire
A1 Gui-shuang Ying
A1 Harini V Gudiseva
A1 Rebecca Salowe
A1 Victoria Addis
A1 Prithvi S Sankar
A1 Roy Lee
A1 Eli J Smith
A1 Joan O'Brien
YR 2023
UL http://bmjophth.bmj.com/content/8/1/e001183.abstract
AB Aim To investigate the prevalence and factors associated with optic disc grey crescent (GC) in African Americans with glaucoma.Methods Stereo optic disc image features from subjects with glaucoma in the Primary Open-Angle African Ancestry Glaucoma Genetics Study were evaluated independently by non-physician graders and discrepancies adjudicated by an ophthalmologist. Risk factors for GC were evaluated by logistic regression models with intereye correlation accounted for by generalised estimating equations. Adjusted ORs (aORs) were generated.Results GC was present in 227 (15%) of 1491 glaucoma cases, with 57 (3.82%) bilateral and 170 (11.4%) unilateral. In multivariable analysis, factors associated with GC were younger age (aOR 1.27, 95% CI 1.11 to 1.43 for every decade younger in age, p=0.001), diabetes (aOR 1.46, 95% CI 1.09 to 1.96, p=0.01), optic disc tilt (aOR 1.84, 95% CI 1.36 to 2.48, p<0.0001), a sloping retinal region adjacent to the outer disc margin (aOR 2.37, 95% CI 1.74 to 3.32, p<0.0001) and beta peripapillary atrophy (aOR 2.32, 95% CI 1.60 to 3.37, p<0.0001). Subjects with GC had a lower mean (SD) value of the ancestral component q0 than those without GC (0.22 (0.15) vs 0.27 (0.20), p=0.001), consistent with higher degrees of African ancestry.Conclusions More than 1 in 10 glaucoma cases with African ancestry have GC, occurring more frequently in younger subjects, higher degrees of African ancestry and diabetes. GC was associated with several ocular features, including optic disc tilt and beta peripapillary atrophy. These associations should be considered when evaluating black patients with primary open-angle glaucoma.All data relevant to the study are included in the article or uploaded as supplemental information. Not applicable.