PT  - JOURNAL ARTICLE
AU  - Kishimoto, Nanami
AU  - Noro, Takahiko
AU  - Kodaka, Fumitoshi
AU  - Kurosawa, Mei
AU  - Itoh, Yoshinori
AU  - Ogawa, Shumpei
AU  - Watanabe, Tomoyuki
AU  - Kubota, Masaomi
AU  - Hori, Kiyotaka
AU  - Shigeta, Masahiro
AU  - Nakano, Tadashi
TI  - Association between personality traits and experience of adverse periocular reactions to topical prostaglandin analogues
AID  - 10.1136/bmjophth-2021-000946
DP  - 2022 Jun 01
TA  - BMJ Open Ophthalmology
PG  - e000946
VI  - 7
IP  - 1
4099  - http://bmjophth.bmj.com/content/7/1/e000946.short
4100  - http://bmjophth.bmj.com/content/7/1/e000946.full
SO  - BMJ Open Ophth2022 Jun 01; 7
AB  - Background Aesthetically unappealing adverse periocular reactions to prostaglandin (PG) eye-drops are a major challenge in glaucoma treatment. This study analysed the personality traits of patients with glaucoma based on a five-factor model and examined the associations between these factors and adverse periocular reactions.Methods One hundred and forty-seven patients with glaucoma were surveyed anonymously regarding their personality traits and how often adverse periocular reactions were experienced.Results The analysis included 117 valid responses (71 men and 46 women, age: 61.9±11.5 years). Patients who experienced hypertrichosis of the eyelashes scored significantly higher on extraversion (p<0.05), with no significant differences in the other four personality traits. Patients who experienced eyelid hyperpigmentation and deepening of the upper eyelid sulcus showed no significant differences in any of the personality traits. Younger patients scored significantly higher on hypertrichosis (p<0.05).Conclusion The experience of adverse reactions differed according to patient age and personality traits. Therefore, eye-drops should be chosen based on these factors.Trial registration number UMIN000035155.Data are available on reasonable request.