TY - JOUR T1 - The 100 most-cited papers on age-related macular degeneration: a bibliographic perspective JF - BMJ Open Ophthalmology JO - BMJ Open Ophth DO - 10.1136/bmjophth-2021-000823 VL - 6 IS - 1 SP - e000823 AU - Andrzej Grzybowski AU - Chen Shtayer AU - Stephen G Schwartz AU - Elad Moisseiev Y1 - 2021/07/01 UR - http://bmjophth.bmj.com/content/6/1/e000823.abstract N2 - The 100 most-cited papers on age-related macular degeneration (AMD) were analysed using a bibliographic study. The bibliographic databases of the Institute for Scientific Information Web of Knowledge were searched, limited to research articles published between 1965 and 2020 in peer-reviewed journals. The papers were ranked in order of number of citations since publication. Five of the top 10 (and 3 of the top 4) papers reported randomised clinical trial results for either anti-vascular endothelial growth factor agents or nutritional supplements. Four of the top 10 papers reported genotype-phenotype associations between AMD and variants in Complement Factor H. This bibliographic study provides perspective and insight into many of the most influential contributions in the understanding and management of AMD and its evolution over time.All data relevant to the study are included in the article or uploaded as online supplemental information. All data relevant to the study are included in the article. ER -