PT - JOURNAL ARTICLE AU - Ehsan Vaghefi AU - Catherine Shon AU - Stacey Reading AU - Taylor Sutherland AU - Victor Borges AU - Geraint Phillips AU - Rachael L Niederer AU - Helen Danesh-Meyer TI - Intraocular pressure fluctuation during resistance exercise AID - 10.1136/bmjophth-2021-000723 DP - 2021 May 01 TA - BMJ Open Ophthalmology PG - e000723 VI - 6 IP - 1 4099 - http://bmjophth.bmj.com/content/6/1/e000723.short 4100 - http://bmjophth.bmj.com/content/6/1/e000723.full SO - BMJ Open Ophth2021 May 01; 6 AB - Objective To evaluate the effect of weightlifting (leg press) on intraocular pressure (IOP).Design Prospective cohort study.Subjects A total of 24 participants met the inclusion criteria and completed the study procedures. Participants had an average age of 22.7±2.7 years and included nine women. The mean baseline IOP was 13.9 mm Hg (SD=2.4) with an average body mass index of 24.5 (SD= 3.1).Methods The maximum load for a single lift was found for each participant. Participants then performed three leg press regimens: one repetition using 95% of maximal load (1RM), six repetitions using 75% of maximal load (6RM) and isometric push against a weight much heavier than maximal load (ISO).Main outcome measure IOP was measured pre-exercise, during and immediately following the exercise using an iCare TA01i rebound tonometer. Blood pressure and HR were being monitored continuously during the lift. Optical coherence tomography images were obtained pre and postexercise session.Results The average maximum weight lifted by our participants was 331.9 Kg (SD=97.3). Transient increased IOP was observed across the 1RM, 6RM and ISO exercises with an average increase in 26.4 mm Hg (23.7 mm Hg to 28.7 mm Hg) to reach an average max IOP of 40.7 mm Hg (27.8 mm Hg to 54.2 mm Hg), with an absolute maximum of 70 mm Hg in one participant.Conclusions There is a transient and dramatic fluctuation in IOP with resistance training. This coupled with regular exposure to resistance training is potentially a significant risk factor for glaucoma. It should be noted that this study has been carried out in a healthy young population, and, thus, the external validity of these results in glaucoma participants requires further investigation.Data are available upon request.