RT Journal Article
SR Electronic
T1 High rate and large intercentre variability in retreatment of retinopathy of prematurity in infants born <24 gestational weeks
JF BMJ Open Ophthalmology
JO BMJ Open Ophth
FD BMJ Publishing Group Ltd
SP e000695
DO 10.1136/bmjophth-2020-000695
VO 6
IS 1
A1 Lundgren, Pia
A1 Jacobson, Lena
A1 Hård, Anna-Lena
A1 Al-Hawasi, Abbas
A1 Larsson, Eva
A1 Gränse, Lotta
A1 Saric, Marie
A1 Sunnqvist, Birgitta
A1 Tornqvist, Kristina
A1 Wallin, Agneta
A1 Holmstrom, Gerd E
A1 Smith, Lois LE
A1 Morsing, Eva
A1 Hellström, Ann
YR 2021
UL http://bmjophth.bmj.com/content/6/1/e000695.abstract
AB Objective Prematurity is a major risk factor for retinopathy of prematurity (ROP). We aimed to elucidate ROP prevalence, treatment and retreatment in infants born before 24 gestational age (GA) weeks in a Swedish cohort.Methods and analysis Infants with completed ROP screening, born at <24 GA weeks, 2007–2018 in Sweden were included. Data of GA, birth weight (BW), sex, neonatal morbidities, maximal ROP stage, aggressive posterior ROP (APROP), ROP treatments, treatment modality and treatment centre were retrieved.Results In total, 399 infants, with a mean GA of 23.2 weeks (range 21.9–23.9) and a mean BW of 567 g (range 340–874), were included. ROP was detected in 365 (91.5%) infants, 173 (43.4%) were treated for ROP and 68 of 173 (39.3%) were treated more than once. As the first treatment, 142 (82.0%) received laser and 29 (16.1%) received intravitreal injection of antivascular endothelial growth factor (anti-VEGF). Retreatment was performed after first laser in 46 of 142 (32.4%) and in 20 of 29 (69.0%) after first anti-VEGF treatment. Retreatment rate was not associated with GA, BW or sex but with APROP, treatment method (anti-VEGF) and treatment centre where the laser was performed (p<0.001). Twenty eyes progressed to retinal detachment, and two infants developed unilateral endophthalmitis after anti-VEGF treatment.Conclusion Infants, born at <24 weeks’ GA, had high rates of treatment-warranting ROP and retreatments. Treatment centre highly influenced the retreatment rate after laser indicating that laser treatment could be improved in some settings.All data relevant to the study are included in the article or uploaded as supplementary information.