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P-15 Descemet’s membrane endothelial keratoplasty without peripheral iridotomy: outcomes and safety profile (category: Research)
  1. Liam Price,
  2. Radhika Patel,
  3. Mukhtar Bizrah,
  4. Ali Mearza
  1. Western Eye Hospital, London, UK


*Correspondence, Liam Price:

Objective Pupil block with raised intraocular pressure (IOP) is a serious complication of Descemet’s membrane endothelial keratoplasty (DMEK). To reduce the risk of pupil block, many surgeons perform a peripheral iridotomy (PI) before or during the procedure, which itself carries a risk of complications. This study demonstrates the outcomes of a method which does not require a PI.

Methods Retrospective, single centre study of DMEK performed under two surgeons. A PI is not made either before or during the surgery as part of their standard technique. Gas is released post-procedure as required in order to avoid iatrogenic pupil block.

Results Fifty-seven consecutive cases of DMEK between January 2018 to August 2021 were included. Fourteen of these cases were combined with phacoemulsification. There were no cases of raised IOP secondary to pupil block in the postoperative period. Three cases of raised IOP were attributable to a history of glaucoma and steroid response. At one year, there was a mean improvement in best-corrected visual acuity (BCVA) of LogMAR 0.44, from a baseline of LogMAR 0.66. The rebubbling rate was 30%, including partial and complete detachments. There was one case of primary graft failure.

Conclusion DMEK without a PI is a safe and effective alternative technique when combined with gas bubble management in the immediate postoperative period. Avoiding the need for a PI would eliminate PI-related complications, while saving on cost and resources.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: .

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