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Original article
New ophthalmic dual-viscoelastic device in cataract surgery: a comparative study
  1. Gaspare Monaco1,
  2. Mariangela Gari1,
  3. Silvia Pelizzari1,2,
  4. Arianna Lanfranchi3,
  5. Giada Ruggi1,
  6. Ilaria Tinto1,
  7. Antonio Scialdone1
  1. 1Ophthalmology, Fatebenefratelli e Oftalmico Hospital, ASST Fatebenefratelli Sacco, Milan, Italy
  2. 2Materials Science, Universita degli Studi di Milano-Bicocca, Milano, Italy
  3. 3Economics and Statistical Sciences, Universita degli Studi di Milano-Bicocca, Milano, Italy
  1. Correspondence to Dr Gaspare Monaco; gaspare.monaco{at}asst-fbf-sacco.it

Abstract

Objective To compare the performance and safety in cataract surgery of two ophthalmic viscoelastic devices (OVDs), each having separate dispersive and cohesive characteristics and different concentrations.

Methods and analysis In this prospective, randomised, controlled clinical study, one eye of each patient was injected with OVD1 (Viscopack14) or OVD2 (DuoVisc) during phacoemulsification and intraocular lens implantation. Endothelial cell count, intraocular pressure (IOP), central corneal thickness (CCT), intraocular inflammation and corrected distance visual acuity (CDVA) were compared 3 months postoperatively.

Results The study enrolled 127 patients. Randomisation assigned 50 eyes of as many patients to each arm of the study. The postoperative mean endothelial cell loss was 14.4% and 7.1% from baseline in the OVD1 and OVD2 groups, respectively (p=0.08). The incidence of IOP spikes at 2 hours was 0% and 8%, respectively (p=0.02). There were intergroup differences in postoperative IOP values, the OVD2 group showed significantly higher values at all of the follow-up visits starting from the 24 hours examination (p<0.05). There was no statistically significant difference in the CCT, intraocular inflammation and CDVA at the end of follow-up.

Conclusion Both OVDs showed similar clinical performances and were equally effective during cataract surgery. Viscopack14 showed more corneal endothelial cell reduction, while DuoVisc had more occurrences of IOP values and spikes. Future studies are mandatory to support these preliminary results.

  • ophthalmic viscoelastic device
  • cataract surgery
  • endothelial cell count
  • intraocular pressure

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjophth-2019-000280

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    Footnotes

    • Contributors GM planned, conducted and reported the work described in the article. MG co-conducted the study. AS revised the manuscript. SP, GR and IT collected the data. AL analysed the data.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Not commissioned; externally peer reviewed.