Article Text
Abstract
Objective To investigate the effect of intraocular lens (IOL) glistenings on visual performance and evaluate a new glistenings grading methodology.
Methods and Analysis Thirty-four patients (34 eyes) were recruited. Corrected distance visual acuity (CDVA), mesopic gap acuity (MGA), functional contrast sensitivity (FCS) and forward light scatter were measured (Advanced Vision and Optometric Tests, City Occupational, London, UK). The IOL centre was imaged and glistenings density graded by three observers using the Miyata scale and a new system. Inter-rater reliability, association between the two grading scales, and correlations between glistenings grades and visual performance parameters were evaluated.
Results The intraclass correlation coefficient between graders for the new grading system was 0.769 (95% Confidence Interval [CI] 0.636 to 0.868). There was a significant association between the Miyata scale and the new grading system for all graders (rs=0.533–0.895, p≤0.001). There was no association between CDVA or MGA and glistenings grade (rs=− 0.098, p=0.583 and rs=0.171, p=0.359, respectively). There was no association between FCS at mesopic light levels and glistenings grade (rs=−0.032, p=0.864), or the straylight parameter and glistenings grade (rs=0.021, p=0.916). No association was found between the integrated straylight parameter and glistenings grade (rs=0.078, p=0.701).
Conclusion The new glistenings grading scale was highly reproducible. In this cohort, glistenings in the same hydrophobic acrylic IOL after cataract surgery were not associated with changes in visual function, as assessed by a series of tests not previously used in glistenings research.
- lens and zonules
- visual perception
- Light scatter
- contrast sensitivity
- mesopic visual acuity
- scotopic visual acuity
- IOL
- glistenings
- intraocular lens implant
- grading scale
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Footnotes
Presented at 23rd European Society of Cataract and Refractive Surgeons (ESCRS) Winter Meeting, Athens, Greece, February 2019
Contributors NS: conception, design, collecting data, analysis and interpretation of data, drafting the article, revising the article. DPSO’B: conception, design, analysis and interpretation of data, drafting the article, revising the article. NM: conception, design, data analysis, drafting the article, revising the article. CCH: conception, design, analysis and interpretation of data, drafting the article, revising the article.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests DPSO’B reports grants and personal fees from Alcon, outside the submitted work. CCH reports grants from Alcon, outside the submitted work.
Patient consent for publication Not required.
Ethics approval This study was approved by London - Bloomsbury Research Ethics Committee. This research conformed to the tenets of the Declaration of Helsinki.
Provenance and peer review Not commissioned; externally peer reviewed.