You are here

  • Home
  • Archive
  • Volume 3, Issue 1
  • Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one

Article Text

Article menu

Download PDFPDF

XML
Original article
Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one
  1. Aitor Lanzagorta-Aresti,
  2. Marta Perez-Lopez,
  3. Juan Maria Davo-Cabrera,
  4. Elena Palacios-Pozo
  1. Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain
  1. Correspondence to Aitor Lanzagorta-Aresti; aitorlanzagorta{at}hotmail.com

Abstract

Objective To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Median preoperative IOP was 27 (22–36.75)  mm Hg for STCT and for 25 (22–28) mm Hg for LTCT group without significant difference (p=0.195). Median postoperative IOP was 4 (3–6.25) mm Hg in STCT group versus 2 (0–5)  mm Hg in LTCT at day 1 (p=0.003); 8.5 (5.75–11.25)  mm Hg (STCT) vs 6 (4–9) mm Hg (LTCT) at week 1 (p=0.079); 17.5 (14.75–22.25)  mm Hg (STCT) vs 13 (10–14) mm Hg (LTCT) at month 1 (p=0.001); 16 (12–20) mm Hg (STCT) vs 12 (10–15) mm Hg (LTCT) at month 3 (p=0.008); 17 (14–20) mm Hg (STCT) vs 12 (10–14) mm Hg (LTCT) at month 6 (p=0.000); 16 (14–20) mm Hg (STCT) vs 14 (10–16) mm Hg (LTCT) at year 1 (p=0.002) and 17.5 (15–19)  mm Hg (STCT) vs 14 (12–16) mm Hg (LTCT) at year 2 (p=0.001). The complete success rate was 54.5 % in STCT and 87 % in LTCT (p=0.018).

Conclusions A long-term and intensive postoperative treatment enhances success rate in DS compared with a standard protocol.

  • deep sclerectomy
  • corticosteroid
  • wound healing
  • glaucoma surgery
  • postoperative treatment

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjophth-2018-000165

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors AL-A planned the study, performed surgery and submitted the study. MP-L made statistics. MP-L, EP-P and JMD-C collected data and reviewed the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent Not required.

    • Ethics approval FOM Institutional Board.

    • Provenance and peer review Not commissioned; externally peer reviewed.