Immunology and functional genomics of Behcet's disease

M Zierhut, N Mizuki, S Ohno, H Inoko, A Gül… - Cellular and Molecular …, 2003 - Springer
Behçet's disease (BD) is a multisystemic inflammatory disorder. Although the cause and
pathogenesis of BD are still unclear, there is evidence for genetic, immunologic and infectious …

New vaccine production platforms used in developing SARS-CoV-2 vaccine candidates

T Ura, A Yamashita, N Mizuki, K Okuda, M Shimada - Vaccine, 2021 - Elsevier
The threat of the current coronavirus disease pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is accelerating the development of potential …

Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci

N Mizuki, A Meguro, M Ota, S Ohno, T Shiota… - Nature …, 2010 - nature.com
Behçet's disease is a chronic systemic inflammatory disorder characterized by four major
manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions 1 . We …

Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1

Y Kirino, G Bertsias, Y Ishigatsubo, N Mizuki… - Nature …, 2013 - nature.com
Individuals with Behçet's disease suffer from episodic inflammation often affecting the
orogenital mucosa, skin and eyes. To discover new susceptibility loci for Behçet's disease, we …

[PDF][PDF] Molecular genetics (HLA) of Behcet's disease

N Mizuki, H Inoko, S Ohno - Yonsei medical journal, 1997 - synapse.koreamed.org
… cloning unidentified genes to identify the pathogenic gene of this disease (Mizuki et al.
1997b). In this paper, we wish to introduce an overview of genetic predisposition underlying the …

Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease

N Mizuki, M Ota, M Kimura, S Ohno… - Proceedings of the …, 1997 - National Acad Sciences
… During nucleotide sequence analyses of the MICA genomic clone, we found a triplet repeat
microsatellite polymorphism of (GCT/AGC) n in the transmembrane (TM) region of the MICA …

Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

…, HA Weich, S Yamagami, S Amano, N Mizuki… - Nature medicine, 2009 - nature.com
… (a) Representative western blot, 5 d after suture placement in Vegfr2 loxP/loxP mouse
corneas treated with pCre or pNull (n = 8 corneas pooled per group). Loading control, …

[HTML][HTML] Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo

…, S Kotake, T Nishida, N Mizuki… - … & visual science, 2003 - iovs.arvojournals.org
… Cell numbers are expressed as the mean ± SD (n = 8). No infiltrating cells were detected in
the aqueous humor from rats without LPS (control group). The dose of prednisolone was 10 …

High-throughput DNA typing of HLA-A,-B,-C, and-DRB1 loci by a PCR–SSOP–Luminex method in the Japanese population

Y Itoh, N Mizuki, T Shimada, F Azuma, M Itakura… - Immunogenetics, 2005 - Springer
We have developed a new high-throughput, high-resolution genotyping method for the detection
of alleles at the human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 loci by combining …

[PDF][PDF] Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error

…, M Morrison, X Zhou, W Chen, N Mizuki… - The American Journal of …, 2013 - cell.com
Refractive errors are common eye disorders of public health importance worldwide. Ocular
axial length (AL) is the major determinant of refraction and thus of myopia and hyperopia. We …