Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects

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Abstract

PURPOSE: The purpose of this study was to evaluate optic nerve blood flow in primary open-angle glaucoma suspect eyes with normal automated visual fields, in an attempt to elucidate how early in the glaucomatous disease process changes in optic nerve blood flow become apparent.

METHODS: Twenty-one eyes (21 patients) suspected of having primary open-angle glaucoma were studied prospectively and compared with a previously reported cohort of 22 eyes (22 patients) with primary open-angle glaucoma and 15 eyes (15 subjects) of age-matched controls. Primary open-angle glaucoma suspect eyes had untreated intraocular pressure greater than 21 mm Hg and normal visual fields using Humphrey program 24-2 or 30-2 with a full threshold strategy. Laser Doppler flowmetry was used to measure optic nerve head blood velocity, volume, and flow at four quadrants in the optic nerve, in the cup, and in the foveola of one eye of each patient. The mean flow from the superotemporal rim, inferotemporal rim, and cup was calculated (Flow3) and identified as the main outcome measure. Measurements from primary open-angle glaucoma suspect eyes were compared with corresponding measurements from controls and eyes with primary open-angle glaucoma; a Student t test was employed with a Bonferroni corrected P value of .025 to account for comparisons of primary open-angle glaucoma suspects both to controls and to eyes with primary open-angle glaucoma.

RESULTS: Compared with controls, Flow3 was 24% lower in primary open-angle glaucoma suspect eyes (P < .0003). In primary open-angle glaucoma suspect eyes, flow was 16% lower in the superotemporal rim (P < .007), 35% lower in the cup (P < .007), and 22% lower in the inferotemporal neuroretinal rim (P < .029) compared with controls. No significant difference between primary open-angle glaucoma suspect and control eyes was seen in the inferonasal rim, superonasal rim, or foveola. No significant difference was detected at any location between primary open-angle glaucoma suspect eyes and eyes with primary open-angle glaucoma.

CONCLUSIONS: Laser Doppler flowmetry detected circulatory abnormalities in primary open-angle glaucoma suspects who did not have any manifest visual field defect. Decreases in flow in glaucoma suspects were similar in magnitude to those of subjects with primary open-angle glaucoma. These data suggest that impaired optic nerve blood flow develops early in the glaucomatous process and does not develop solely as a result of glaucoma damage.

Section snippets

Methods

Laser Doppler flowmetry measurements were obtained prospectively in 21 eyes (21 patients) with elevated intraocular pressure and normal automated visual fields (“primary open-angle glaucoma suspect eyes”), and were compared with a previously studied cohort of 15 eyes (15 patients) of age-matched controls and 22 eyes (22 patients) with primary open-angle glaucoma. Patients were referred from one author’s (J.R.P.-S.) university-based referral practice. The study protocol was approved by the

Results

No significant difference was noted in age, mean blood pressure, and perfusion pressure between the primary open-angle glaucoma suspect, control, and primary open-angle glaucoma groups (Table 1). Intraocular pressure was significantly higher in the primary open-angle glaucoma suspect group than controls (P < .005) or primary open-angle glaucoma (P < .0008).

Flow3, Vel3, and Vol3 are shown in Table 3. Compared with controls, Flow3 was 24% lower in primary open-angle glaucoma suspect eyes (P <

Discussion

In comparison to controls, we detected a significantly lower average blood flow in the optic nerve of subjects suspected of having primary open-angle glaucoma. As we previously identified in the primary open-angle glaucoma eyes,1 significantly lower blood flow was noted in the areas most sensitive to glaucoma damage, namely the superotemporal and inferotemporal neuroretinal rims. The largest decrease in flow was seen in the cup of primary open-angle glaucoma suspect eyes, which was also similar

Acknowledgements

The authors thank Maureen Maguire, PhD, Professor of Ophthalmology, Director of the Center for Preventative Ophthalmology and Biostatistics, University of Pennsylvania School of Medicine, for her assistance with the statistical analysis.

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    This investigation was supported by the National Institutes of Health grants NEI EY11479 and R21 EY10964, Bethesda, Maryland, the Vivian Simkins Lasko Research Fund, the Paul and Evanina Mackall Trust, and an unrestricted grant from Research to Prevent Blindness, New York, New York.

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