Men, women and blindness

Very few researchers have attempted a formal comparison of the eye health of women and men. Many studies have been carried out either on all male samples or on mixed groups where findings from male and female subjects are not analysed separately. But it is clear that vision disorders do affect women disproportionately.1–3 A recent report on gender inequities in health problems indicated that five of the six eye conditions listed had a female to male excess of 1.2 or more4 This ratio holds true (although for different reasons) for virtually all the preventable and treatable blinding conditions in the world, including cataract and trachoma in particular. Prevalence only reaches equality in less common diseases such as age-related macular degeneration.

Cataracts dominate all causes of blindness and visual impairment around the world, and it is clear that women are more likely than men to develop them. A recent global survey estimated that two-thirds of all cataract blindness was in women.5 However, ratios vary in different settings. One study in Pakistan, for example, found that the prevalence of cataract blindness was twice as high among women as among men.6 Evidence from epidemiological studies suggests that biological sex differences play a significant part in this excess of cataracts among women but the mechanisms behind this are not yet clear.

The second major example of inequities in vision between women and men is trachoma which is still endemic in more than 50 countries. Over time, repeated infections result in the development of scar tissue on the inside of the eyelid. This may eventually lead to trichiasis, from a resultant entropion, eventually leading to corneal abrasion, ulceration, perforation and ultimately the loss of sight.

Girls and women are infected with trachoma between two and four times more frequently than boys and men at all ages.7 They are also nearly twice as likely as men to develop the more serious trichiasis which results from repeated episodes of infection.8 About 80–85 million women are estimated to have active trachoma; 8 million to have trichiasis and 3 million to be blind from the infection.7,ⁱ In this case, however, there is little or no evidence of a sex-linked predisposition for trachoma. Hence, the excess risk they bear throughout their lives suggests that unlike cataracts, social factors rather than biology are likely to be mainly responsible.

Around three-quarters of vision problems are either preventable or correctable so that variations between women and men are not ‘natural’ and unavoidable. Instead, they reflect a combination of inherent biological vulnerabilities and socially constructed inequities that need urgent attention if women and men in different parts of the world are to realise their potential for eye health.

Sex and gender: the wider debate

Most of the differences between the health of women and men have traditionally been framed by medical researchers within the language of biology, with sex differences in reproductive systems as the focal point of differentiation.9 However, the last decade in particular has seen a shift towards what has been referred to as a ‘social determinants of health’ approach.10 This emphasises the fact that patterns of health and illness reflect not just biological variables but also a wide range of external influences.

A major part of this reconceptualisation has been a recognition that differences between the daily lives and physical circumstances of women and men (including access to effective healthcare) will play a significant part in shaping inequalities in their respective experiences of health and illness. As part of this refocussing, the concept of ‘gender difference’ has increasingly been used by researchers alongside that of the more traditional ‘sex difference’. This is potentially an important step forward in recognising the distinction between social and biological domains.

But too often these terms continue to be used interchangeably on the assumption that ‘gender’ is simply a more modern or even ‘politically correct’ word for ‘sex’. In reality, however, this changing terminology is more than a mere semantic shift. Sex is still the appropriate term for describing those differences which are biological in origin, deriving from an individual’s chromosomes. Gender on the other hand refers to the differences in social, economic and cultural resources allocated to male and female individuals. As recent debates have shown, it is often a combination of influences from both these arenas that shape variations in health between women and men across a range of settings.11–13

The last decade has seen a growing body of research exploring the relationships between the biological and the social in a number of medical fields. The USA has been at the centre of this work with protocols increasingly being required by funders to reflect this methodological shift. Research on coronary heart disease and HIV, for example, have both provided important illustrations of the added value of this more integrated approach.ⁱⁱ But much less has been done to explore these issues in some of the smaller medical specialties such as ophthalmology.ⁱⁱⁱ One starting point to remedy this deficit would be the development of more studies focussing on either men or women in different age cohorts. But most importantly it will be essential that all research designs take the potential significance of sex and gender into account in framing the questions to be explored, in calculating sample size to include adequate sub samples and in analysing any differences detected between women and men.

How should we explain inequalities in vision between women and men?

At first glance, we might assume that it is differences in life expectancy that are the major factors explaining men’s advantage. Most major eye problems are associated with ageing and women now live longer than men in most parts of the world. Hence, more of them are likely to survive to develop vision problems. However, this is certainly not the only explanation since women are more affected than men by most eye diseases at all ages. They also appear to receive less effective and appropriate eye care than men. We therefore need to look at the social as well as the biological factors that put females at greater risk of visual impairment and ultimately blindness.

Obstacles to gender sensitivity in eye care services

Over the last decade a range of studies have explored the differential use made by women and men of a range of health services. The general conclusion seems to be that even when their reproductive care is excluded, women use services more than men.25 In recent years, this has been demonstrated with particular clarity in the context of HIV with men significantly less likely than women to obtain antiretroviral drugs.26,^vi It is striking, therefore, that the pattern seems to be reversed in the context of eye care in those areas where the burden of blindness is most severe.

The adequacy of eye care varies between rich and poor settings and it is in the low-income countries of Africa and Asia that the lack of effective services is most common.27 This is true for both women and men but especially for women. Services can of course be either preventive or curative depending on the condition in question. The sex-differentiated biological origins of cataract mean that prevention is not possible. However, surgery can be extremely effective in improving or totally restoring vision. In the case of trachoma on the other hand, prevention is possible through a range of social, economic and cultural strategies. And in the absence of prevention, treatment can include both antimicrobial drugs (annual doses of azithromycin) and surgery. Yet, despite these potentially effective interventions, gender inequalities in blindness remain largely unresolved.

A recent study of 23 low-income and middle-income countries found that men in need of cataract surgery were 1.71 times more likely to get it than women in the same degree of need.28 Because women have a higher incidence of cataract and tend to have longer life expectancy than men, equity prescribes that they should account for 60–65 per cent of all cataract operations. Indeed, a recent estimate suggested that if women’s access to cataract surgery was equal to that of men, the overall incidence of global blindness would decrease by 12.5%.6

In the case of trachoma, SAFE is the main strategy used to attack the disease through both prevention and treatment.^vii An essential element in this programme is education for women (and men) about the importance of face washing and other hygiene measures. This in turn will require significant environmental improvements particularly easy access to clean water and sanitation. Those who are already infected can usually be helped with a combination of drugs and sometimes surgery.29 But again, there is clear evidence of inequality and discrimination in service delivery and too little emphasis on gender in evaluation. A number of studies have shown, for example, that women are more likely than men to have recurrence of trichiasis after surgery.7 This can have several causes including the fact that women often have to wait longer for surgery until the trichiasis is more severe.

Any attempt to understand these gaps between need and use of services must begin with a wider perspective on gender divisions across a range of settings. There is now a vast literature highlighting the inequalities that exist in income, power and status between women and men. Though these vary in form and intensity between communities, there are obvious similarities that play a key role in limiting women’s access to eye care. Central to these inequalities is women’s limited influence over decision-making in both community and national settings. Hence, they are unlikely to be able to exert pressure for improving the provision of infrastructure.

Women are also likely to have access to fewer resources than men.30 Hence, the way that eye care if funded will have important gender implications. This is especially important in the context of household budgets where scarce resources are more likely to be used for the benefit of boys and men and women will have little power to alter such decisions.28 31 32 Even if resources are available, women may be hindered by the limitations on their freedom to travel without an escort and the need to find alternative carers for those for whom they are normally responsible.

Women’s use of services may also be limited by their own lack of knowledge especially given the high rates of illiteracy among those in areas where visual impairment and blindness are most common. This is likely to be compounded by fear of the unknown as well as feelings of lack of worth. Too often, older women are likely to have poor self-esteem and low expectations. Indeed, there is considerable evidence that older women in particular do not perceive their sight as being as bad as a clinical examination would suggest.33 Thus, most try to carry on their routine tasks despite worsening disability including increased risk of falls and fractures34 as well as isolation and depression.