(A) Mean (±SD) of OCT optic nerve parameters in children with PCG and age-equivalent, gender-equivalent and ethnicity-equivalent healthy controls (the two groups were compared statistically using linear mixed models); (B) mean (±SD) of optic nerve parameters in adults with POAG and age-equivalent, gender-equivalent and ethnicity-equivalent healthy controls (the two groups were compared statistically using linear mixed models); (C) comparison of optic nerve parameters relative to their control values (patient values/mean control value×100%) in children with PCG and adults with POAG
| (A) Children with PCG compared with controls | ||||
| PCG | Controls | Linear mixed model | ||
| Mean±SD | Mean±SD | F | P value | |
| Disc diameter (°) | 5.596±0.851 | 6.014±0.578 | 3.28 | 0.078 |
| Cup:disc ratio | 0.668±0.173 | 0.398±0.178 | 26.46 | <0.000 |
| Cup diameter (°) | 3.782±1.288 | 2.381±1.061 | 15.65 | <0.000 |
| Cup area (µm) | 1491.3±778.2 | 503.6±451.7 | 25.93 | <0.000 |
| Cup depth (µm, from rim edges) | 781.8±196.1 | 473.5±144.0 | 34.08 | <0.000 |
| Rim width (°) | 1.814±0.947 | 3.633±1.198 | 31.87 | <0.000 |
| Rim area (µm) | 215.0±212.4 | 590.3±309.5 | 21.62 | <0.000 |
| Nasal RNFL at 6° from disc centre (µm) | 51.1±20.0 | 66.1±21.1 | 5.29 | 0.028 |
| Temporal RNFL at 6° from disc centre (µm) | 59.6±17.6 | 60.4±13.0 | 0.02 | 0.894 |
| Age (years) | 4.45±2.82 | 4.73±2.81 | 0.14 | 0.711 |
| (B)Adults with POAGcompared withcontrols | ||||
| Adult glaucoma | Controls | T-test | ||
| Mean±SD | Mean±SD | F | Pvalue | |
| Disc diameter (°) | 5.536±0.612 | 5.180±0.513 | 1.47 | 0.175 |
| Cup:disc ratio | 0.804±0.109 | 0.551±0.087 | 8.17 | 0.000 |
| Cup diameter (°) | 4.470±0.876 | 2.866±0.612 | 6.18 | 0.000 |
| Cup area (µm) | 1636±633.4 | 695±175.6 | 5.79 | 0.000 |
| Cup depth (µm, from rim edges) | 668.0±148.8 | 572.5±90.7 | 1.83 | 0.100 |
| Rim width (°) | 1.066±0.531 | 2.314±0.449 | 8.00 | 0.000 |
| Rim area (µm) | 79.03±85.6 | 294.8±128.4 | 5.61 | 0.000 |
| Nasal RNFL at 6° from disc centre (µm) | 46.0±9.08 | 57.8±18.19 | 1.86 | 0.096 |
| Temporal RNFL at 6° from disc centre (µm) | 47.9±8.95 | 50.4±5.1 | 0.74 | 0.479 |
| Age (years) | 67.0±6.96 | 66.8±7.50 | 0.07 | 0.949 |
| (C)Comparison ofoptic nerveparameters relative to their control values | ||||
| PCG | Adults | Linear mixed model | ||
| Mean±SD | Mean±SD | F | Pvalue | |
| Disc diameter (°) | 93%±14% | 107%±12% | 8.64 | 0.006 |
| Cup:disc ratio | 168%±43% | 146%±20% | 1.83 | 0.186 |
| Cup diameter (°) | 159%±54% | 156%±31% | 0.00 | 0.966 |
| Cup area (µm) | 296%±155% | 235%±91% | 0.26 | 0.611 |
| Cup depth (µm, from rim edges) | 165%±41% | 117%±26% | 6.65 | 0.014 |
| Rim width (°) | 50%±26% | 46%±23% | 0.14 | 0.708 |
| Rim area (µm) | 36%±36% | 27%±29% | 0.95 | 0.337 |
| Nasal RNFL at 6° from disc centre (µm) | 83%±42% | 76%±32% | 0.39 | 0.538 |
| Temporal RNFL at 6° from disc centre (µm) | 99%±29% | 97%±17% | 1.01 | 0.323 |
OCT, optical coherence tomography; PCG, primary congenital glaucoma; POAG, primary open-angle glaucoma; RNFL, retinal nerve fibre layer.