Table 1

Repeated-measures analysis of variance of measurements for treatment, time and interaction (treatment-by-time) effects. Ordinal data were converted to rank-values prior to assessment. Data are presented as p values

	p Value
	Treatment	Time	Interaction
General evaluation
Best corrected visual acuity (logMAR)	0.96	0.15	0.33
Eyelid itching grade	0.16	0.95	0.62
Eyelid pain grade	0.33	0.77	0.38
Ocular surface evaluation
Bulbar conjunctival hyperaemia	0.15	0.18	0.92
Palpebral erythema	0.94	0.14	0.35
Sodium fluorescein staining score (out of 55)	0.12	0.62	0.16
Lissamine green staining score (out of 55)	0.54	0.35	0.15
Lid wiper epitheliopathy grade	0.27	0.79	0.24
Tear film evaluation
Tear film lipid layer grade	0.32	0.13	0.25
Tear evaporation rate (g/m²/h)	0.31	0.15	0.47
Non-invasive tear film break-up time (s)	0.67	0.74	0.51
Tear film osmolarity (mOsmol/kg)	0.66	0.58	0.25
Tear meniscus height (mm)	0.83	0.67	0.26
Impression cytology
MMP-9 expression	0.75	0.69	0.61
IL-6 expression	0.23	0.13	0.10
MUC5AC expression	0.39	0.55	0.31

IL-6, interleukin-6; MMP-9, matrix metalloproteinase-9; MUC5AC, mucin-5AC; SD standard deviation.