Cumulative estimates for incident early AMD, incident late AMD, and progression by study and refined age groups
| (A) Cumulative incidence of early AMD | (B) Cumulative incidence of late AMD (definition 1)* | ||||||
| Study | Age (years)† | N events/n‡ | Incidence (%) | 95% CI | N events/n‡ | Incidence (%) | 95% CI |
| KORA-Fit | All | 33/484 | 6.8 | 4.7 to 9.4 | 3/484 | 0.6 | 0.1 to 1.8 |
| (34,45) | 15/268 | 5.6 | 3.2 to 9.1 | 0/268 | 0.0 | 0.0 to 1.4 | |
| (45,50) | 8/136 | 5.9 | 2.6 to 11.3 | 1/136 | 0.7 | 0.0 to 4.0 | |
| (50,55) | 10/80 | 12.5 | 6.2 to 21.8 | 2/80 | 2.5 | 0.3 to 8.7 | |
| KORA-FF4 | All | 46/332 | 13.9 | 10.3 to 18.0 | 7/332 | 2.1 | 0.9 to 4.3 |
| (53,60) | 14/149 | 9.4 | 5.2 to 15.3 | 4/149 | 2.7 | 0.7 to 6.7 | |
| (60,65) | 19/113 | 16.8 | 10.4 to 25.0 | 1/113 | 0.9 | 0.0 to 4.8 | |
| (65,75) | 13/70 | 18.6 | 10.3 to 29.7 | 2/70 | 2.9 | 0.3 to 9.9 | |
| AugUR | All | 63/518 | 12.2 | 9.5 to 15.3 | 3/518 | 0.6 | 0.1 to 1.7 |
| (70,75) | 24/224 | 10.7 | 7.0 to 15.5 | 1/224 | 0.4 | 0.0 to 2.5 | |
| (75,80) | 22/198 | 11.1 | 7.1 to 16.3 | 1/198 | 0.5 | 0.0 to 2.8 | |
| (80,96) | 17/96 | 17.7 | 10.7 to 26.8 | 1/96 | 1.0 | 0.0 to 5.7 | |
| (C) Cumulative incidence of late AMD (definition 2)§ | (D) Cumulative progression from early to late AMD | ||||||
| Study | Age (years)† | N events/n‡ | Incidence (%) | 95% CI | N events/n‡ | Progression (%) | 95% CI |
| KORA-Fit | All | 8/506 | 1.6 | 0.7 to 3.1 | 5/22 | 22.7 | 7.8 to 45.4 |
| (34,45) | 1/275 | 0.4 | 0.0 to 2.0 | 1/7 | 14.3 | 0.4 to 57.9 | |
| (45,50) | 2/144 | 1.4 | 0.2 to 4.9 | 1/8 | 12.5 | 0.3 to 52.7 | |
| (50,55) | 5/87 | 5.7 | 1.9 to 12.9 | 3/7 | 42.9 | 9.9 to 81.6 | |
| KORA-FF4 | All | 14/348 | 4.0 | 2.2 to 6.7 | 7/16 | 43.8 | 19.8 to 70.1 |
| (53,60) | 4/151 | 2.6 | 0.7 to 6.6 | 0/2 | 0.0 | 0.0 to 84.2 | |
| (60,65) | 3/120 | 2.5 | 0.5 to 7.1 | 2/7 | 28.6 | 3.7 to 71.0 | |
| (65,75) | 7/77 | 9.1 | 3.7 to 17.8 | 5/7 | 71.4 | 29.0 to 96.3 | |
| AugUR | All | 23/628 | 3.7 | 2.3 to 5.4 | 20/110 | 18.2 | 11.5 to 26.7 |
| (70,75) | 6/267 | 2.2 | 0.8 to 4.8 | 5/43 | 11.6 | 3.9 to 25.1 | |
| (75,80) | 11/244 | 4.5 | 2.3 to 7.9 | 10/46 | 21.7 | 10.9 to 36.4 | |
| (80,96) | 6/117 | 5.1 | 1.9 to 10.8 | 5/21 | 23.8 | 8.2 to 47.2 | |
Shown are 18 year, 14 year, and 3 year cumulative estimates and 95% CI for incidence and progression for the three studies (KORA-Fit, KORA FF4, AugUR, respectively), overall and by refined age groups. For AMD classification, 3CACSS12 was applied here (analogous estimates for CC36 in online supplemental table 3).
*Considering individuals with no AMD at baseline (definition 1).
†Age at baseline.
‡Number of events/number of persons at risk.
§Considering individuals with no or early AMD at baseline (definition 2).
AMD, age-related macular degeneration; AugUR, Altersbezogene Untersuchungen zur Gesundheit der Universität Regensburg; 3CACSS, Three Continent AMD Consortium Severity Scale; KORA-Fit / KORA-FF4, Kooperative Gesundheitsforschung in der Region Augsburg.