Deterministic sensitivity analysis cost-effectiveness results
| Usual care (usual care) | Intervention (early PRP) | |
| Patients in the intervention arm receive PRP treatment at the early PDR or early PDR and CSDMO instead of the severe NPDR or severe NPDR or CSDMO stage. | ||
| Total mean costs (£) | £3853 | £3725 |
| Total mean QALYs | 7.8236 | 7.8645 |
| ICER (cost per QALY gained) | Dominated | |
| PRP treatment is administered in one sitting (two laser treatments for two eyes) or in four sittings (eight laser treatments for two eyes) instead of two sittings (four laser treatments for two eyes). We have assumed that the risk of DMO remains the same. | ||
| One sitting | ||
| Total mean costs (£) | £3762 | £2452 |
| Total mean QALYs | 7.8236 | 7.9572 |
| ICER (cost per QALY gained) | Two sittings are dominated by one sitting | |
| Four sittings | ||
| Total mean costs (£) | £4035 | £3353 |
| Total mean QALYs | 7.8236 | 7.9572 |
| ICER (cost per QALY gained) | Two sittings are dominated by four sittings. | |
CSDMO, clinically significant diabetic macular oedema; DMO, diabetic macular oedema; ICER, incremental cost-effectiveness ratio; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy; PRP, panretinal photocoagulation; QALYs, quality-adjusted life years.