Article Text
Abstract
Objective To evaluate the reproducibility of in vivo crystalline lens measurements obtained by novel commercially available swept-source (SS) optical coherence tomography (OCT) specifically designed for anterior segment imaging.
Methods and analysis One eye from each of 30 healthy subjects was randomly selected using the CASIA2 (Tomey, Nagoya, Japan) in two separate visits within a week. Each eye was imaged twice. After image scanning, the anterior and posterior lens curvatures and lens thickness were calculated automatically by the CASIA2 built-in program at 0 dioptre (D) (static), −1 D, −3 D and −5 D accommodative stress. The intraobserver and intervisit reproducibility coefficient (RC) and intraclass correlation coefficient (ICC) were calculated.
Results The intraobserver and intervisit RCs ranged from 0.824 to 1.254 mm and 0.789 to 0.911 mm for anterior lens curvature, from 0.276 to 0.299 mm and 0.221 to 0.270 mm for posterior lens curvature and from 0.065 to 0.094 mm and 0.054 to 0.132 mm for lens thickness, respectively. The intraobserver and intervisit ICCs ranged from 0.831 to 0.865 and 0.828 to 0.914 for anterior lens curvature, from 0.832 to 0.898 and 0.840 to 0.933 for posterior lens curvature and from 0.980 to 0.992 and 0.942 to 0.995 for lens thickness. High ICC values were observed for each measurement regardless of accommodative stress. RCs in younger subjects tended to be larger than those in older subjects.
Conclusions This novel anterior segment SS-OCT instrument produced reliable in vivo crystalline lens measurement with good repeatability and reproducibility regardless of accommodation stress.
- Lens and zonules
- imaging
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Footnotes
Acknowledgement The authors wish to thank Miss Kobori and Kumagai for help in preparing the study and clinical input.
Contributors TS, NK and SI conceived and designed the experiments. TS, NK, SI and HI collected the samples and performed the experiments. TS, HI and NK analysed the data. TS and HI wrote the manuscript and NK, NY, IK and KS reviewed the manuscript.
Funding This study was supported in part by Takeda Science Foundation, Tokyo, Japan; Grant-in-Aid for Young Researchers from Saitam Medical University Hospital and Japan Society for the Promotion of Science KAKENHI grant no 15K21335.
Competing interests TS: Alcon (travel grant). N
K, SI, HI, NY, IK, KS: none.
Provenance and peer review Not commissioned; externally peer reviewed.