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Abstract
Glaucoma is the leading cause of irreversible blindness. It is estimated that as many as 3.2 million people worldwide experience blindness due to glaucoma, including open-angle glaucoma (OAG). Until now, there is no definite mechanism related to the incidence of OAG. However, increased intraocular pressure (IOP) is considered to be the most important risk factor. Several current studies show that there is a significant relationship between hypertension (HTN) and IOP. In particular, several epidemiological studies have shown that an increase in systemic blood pressure (BP) is associated with an increase in IOP. However, several studies report that high BP provides a protective effect at a young age against the incidence of OAG. Therefore, this literature aims to explore the effect of HTN on the incidence of OAG. In this review, search for the literature using keywords that match the topic, then a gradual screening was carried out with the predetermined eligibility criteria. From 3711 studies, 16 studies matched the criteria having a total sample size of 72 212 and then a quantitative meta-analysis was conducted. The results showed a risk ratio of 1.69 (95% CI 1.50 to 1.90) in the HTN group. However, from our qualitative synthesis, we found that people who have an unstable diastolic blood pressure (DBP), either high or low, are both able to increase the risk of OAG events. In conclusion, we found that HTN was able to increase the risk of OAG and DBP instability, whether high or low, can also increase the risk of OAG incidence.
- hypertension
- risk factor
- blood pressure
- intraocular pressure
- open-angle glaucoma
Data availability statement
No data are available.
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Introduction
Glaucoma is the leading cause of irreversible blindness worldwide. According to WHO report, it was estimated that there are 3.2 million people who have experienced blindness due to glaucoma.1 Glaucoma is generally defined as an optic neuropathy characterised by damage to the retinal ganglion cells (RGCs) in the inner core layer associated with structural damage to the optic nerve and loss of field of view.2 Based on the morphology of angular iridocorneal, glaucoma is divided into the following two types: open-angle glaucoma (OAG) and angle-closed glaucoma.3
Until recently, the pathogenesis of OAG was not fully understood. Increased intraocular pressure (IOP) is considered the most critical risk factor.4 IOP is the pressure generated by the contents of the eyeball against the eyeball wall. The balance between the production of aqueous humour by the ciliary corpus and drainage through the two meshwork and uveoscleral trabecular pathways then empties into the episclera veins, which is a mechanism that maintains the IOP stability.4 5 Pressure and strain on the lamina cribrosa induced by an increase in IOP cause compression, deformation and remodelling, which results in damage to RGC axons.4 6
Maintaining the stability of IOP is a challenge to answer the problem of blindness that exists around the world, especially those caused by glaucoma. Some of the results of this study indicate that there is a significant relationship between hypertension (HTN) and IOP, which is a risk factor for the occurrence of primary open-angle glaucoma (POAG).7 In particular, several epidemiological studies have reported that an increase in systemic blood pressure (BP) is associated with a slight increase in IOP.8 This is because the increase in BP increases episclera venous pressure so that the aqueous clearance (excretion of aqueous humour) will decrease, which will cause an increase in IOP.9 However, until recently, the relationship between BP and the incidence of glaucoma is still being debated. Some studies report that there is no correlation between systemic BP with IOP and the incidence of glaucoma.10 Even several other studies reported that in younger patients, HTN gave a protective effect by increasing the ocular perfusion pressure (OPP) or eye perfusion pressure against the incidence of glaucoma.11
Previously, Zhao et al12 conducted a systematic review and meta-analysis on the same topic in 2014, but we found several primary studies conducted after a systematic review was compiled; this systematic study focused on looking at the direct relationship between HTN and the incidence of OAG. This systematic study aims to further explore the mechanism and relationship between HTN and the incidence of OAG and to update the current results so that later it can become one of the primary considerations for providing screening and special attention to hypertensive patients who are at risk for OAG.
Methods
Literature search
In this systematic review, a literature search will be conducted on 22 July 2020 from various databases, namely PUBMED, MEDLINE and EMBASE, using the keywords ((essential hypertension) OR (high blood pressures) OR (high blood pressure) OR (systemic hypertension) OR (hypertension) AND (Primary Open-Angle Glaucoma)). In addition, several valid studies outside the database will be included if they match the criteria.
Study eligibility and screening criteriasd
The study criteria that will be included in this systematic review are as follows: (1) publications in the last 15 years; (2) research design in the form of observational study; (3) the language used is in the form of Indonesian or English; (4) exposure in the form of systemic HTN (BP ≥140/90 mm Hg/currently taking antihypertensive drugs/self-reported) and (5) evaluated OAG as the outcome. The study criteria that will be excluded are as follows: (1) abstract not available; (2) full-text paper is not available and (3) wrong publication type (letter, newspaper, case reports and comment article).
Literature studies that match the eligibility criteria will be included, while those that do not match the criteria will be excluded with reasons. The conflicts in grouping the studies will be discussed together until a decision is reached. The results of the screening of literature studies will later be reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis.
Data collection
Data collection will be carried out for all included studies. The data that will be collected include the following: (1) the main author; (2) year of publication; (3) the place where the research was conducted; (4) study design; (5) number of samples; (6) gender of samples; (7) mean/range age of samples; (8) type of outcome and (9) incidence rate data from exposure and outcome.
Data collection was carried out by one reviewer (ATFZ) and then cross-checked by other reviewers (RN, AI, NW, FK and AMAKG). If in the included literature study there is incomplete data, the reviewer will contact the author of the study; if the author does not respond, the study is then excluded with the reviewer’s agreement.
Quality assessment
Quality assessment was carried out by two reviewers (ATFZ and AMAKG) using the Newcastle-Ottawa Scale. In a study with cross-sectional and case–control design, an assessment was carried out on the following three main aspects: selection, comparability and exposure. Meanwhile, in a study with a cohort design, the exposure aspect was replaced by assessing the outcome aspect. The assessment is done by discussing point by point, every point that has a low risk of bias, we will give one star, except for the aspect of compatibility, which allows for two stars. Studies with more stars show a better quality of the study.
Statistical analysis
The data obtained were processed using Review Manager V.5.3. We performed three meta-analyses intending to assess the association between age, gender and HTN with the incidence of OAG. The first meta-analysis was performed by including the incidence of glaucoma in the hypertensive and non-hypertensive groups to measure the risk ratio (95% CI) of studies that met the criteria for inclusion in the quantitative analysis. In the first meta-analysis, we did a subgroup analysis by dividing the three groups of study based on the design of the study, which is a cross-sectional, case–control and cohort. The second meta-analysis was performed by including the mean age in glaucoma and non-glaucoma groups to measure the mean difference. The third meta-analysis done by inserting the glaucoma incidence rate for each group is gender male and female. The heterogeneity of the statistical analysis was seen from the I2 value.
Publication bias
Publication bias is evaluated subjectively by looking at the funnel plot. In addition, for situations where the heterogeneity was too high, Duval and Tweedie’s trim-and-fill analysis was performed to recalculate effect sizes after removing all studies that could have caused publication bias.11
Results
Literature search and result of screening
In this systematic review, after searching literature studies from various databases, namely PUBMED, MEDLINE and EMBASE, using the keywords resulted in 3711 studies, which were then filtered according to predetermined criteria.
Before the screening, 52 duplicate studies were excluded. Furthermore, 3659 study titles and abstracts were screened independently by three reviewers (RN, ATFZ and AMAKG). A total of 3641 studies were excluded because they did not comply with predetermined criteria. The next 18 studies were screened by reading the text thoroughly. As a result, two studies were excluded because of incomplete data, incomplete data in the form of the incidence of glaucoma in the HTN group and the control group, so that the remaining 16 studies met the criteria with a total sample size of 72 212 and were included for qualitative and quantitative analysis. Full details of search and filter results are presented in figure 1.
Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Characteristics of the eligible studies
The 16 included studies were primary studies conducted in 13 different countries with a total sample size of 72 212. Of the 16 studies, 11 used a cross-sectional design, 3 case–control and 2 cohorts. Twelve studies assessed the outcome of POAG, while the other four studies assessed the outcome of OAG. Full details of the characteristics of the included studies are presented in table 1.
Characteristics of inclusion studies
Quality assessment result
The quality assessment of the 16 included studies was represented by the total stars obtained for each study from the range 0 to 9. In general, the quality of the included studies was good; the lowest score was five stars in three studies, seven stars were found mostly in five studies, while the highest score was nine stars in two studies. The complete details of the quality assessment are presented in table 2.
Quality assessment result using Newcastle-Ottawa Scale
Statistical test results (meta-analysis)
Dichotomous data in the form of the incidence of OAG from each group (HTN and non-HTN) were collected from 16 included studies. Furthermore, the data are entered in a statistical test using the Review Manager V.5.3 application to see the risk ratio using the random-effects model. During meta-analysis, we did a subgroup analysis by dividing the three groups of study based on the design of the study, which is a cross-sectional, case–control and cohort. The results showed a significant risk ratio of 1.69 (95% CI 1.50 to 1.90). Overall effect: Z=8.6 (p<0.00001) and heterogeneity of τ2=0.02; χ2=28.59; df=15 (p=0.02); I2=48%. These results are presented in the form of a forest plot in figure 2A.
(A) Forest plot subgroup meta-analysis (hypertension vs non-hypertension) on the incidence of OAG and (B) funnel plot meta-analysis (hypertension vs non-hypertension) on the incidence of OAG. OAG, open-angle glaucoma.
Continuous data such as the mean age of each group (OAG and non-OAG) collected from 11 studies were included. Furthermore, the data are entered in a statistical test to see the mean difference using the random-effects model. The results showed a significant mean difference of 4.21 (95% CI 0.70 to 7.72). Overall effect: Z=8.6 (p<0.00001) and τ2 heterogeneity=0.02; χ2=418.01; df=10 (p=0.02); I2=98%. The results are presented in the form of forest plots in figure 3A.
(A) Forest plot meta-analysis mean age on glaucoma vs non-glaucoma groups and (B) funnel plot meta-analysis mean age on glaucoma vs non-glaucoma groups. Each Black circle is a study that is distributed based on the x-axis: Risk ratio and the y-axis: SE of RR. So, one black circle represents one study.
Dichotomous data in the form of the incidence of OAG from each group (male and female) were collected from 12 included studies. Furthermore, the data are included in the statistical test to see the risk ratio using the fixed effect model. The results showed a significant risk ratio of 4.21 (95% CI 1.20 to 1.41). Overall effect: Z=6.4 (p<0.00001) and heterogeneity χ2=31.22; df=11 (p=0.001); I2=65%. The results are presented in the form of forest plots in figure 4A .
(A) Forest plot subgroup meta-analysis (gender) on the incidence of OAG and (B) funnel plot meta-analysis (gender) on the incidence of OAG. OAG, open-angle glaucoma. Each Black circle is a study that is distributed based on the x-axis: Risk ratio and the y-axis: SE of RR. So, one black circle represents one study.
Publication bias
The funnel plot in figure 2B and figure 3B shows the asymmetrical shape of the study distribution, indicating a low risk of publication bias in this meta-analysis. However, the funnel plot in figure 4B shows the asymmetrical shape of the study distribution, indicating a high risk of publication bias in this meta-analysis, with a cumulative subjective assessment.
Discussion
The results of the meta-analysis showed that people with systemic HTN had a significantly 1.71-fold risk of developing glaucoma compared with non-hypertensive people (1.71 (95% CI 1.58 to 1.85)) with minimal publication bias assessed subjectively using a funnel plot. This is in line with various previous primary studies which reported a significant relationship between systemic HTN and the incidence of OAG.11 13–17 A meta-analysis assessing the effect of intraocular and BP reported that a 10 mm Hg increase in systolic BP resulted in an increase in IOP by 0.26 mm Hg, whereas an increase in diastolic BP by 5 mm Hg increased IOP by 0.17 mm Hg.12
The results of the second meta-analysis showed that the average age of patients with OAG was higher with a mean difference result (4.21 (95% CI 0.7 to 7.72)). The results of another meta-analysis showed that the female gender had a higher risk of experiencing OAG with the result of a risk ratio (1.3 (95% CI 1.2 to 1.41)). This shows that in addition to HTN, age and gender also contribute to the incidence of OAG.
High BP can increase IOP through two mechanisms, first, an increase in the production of aqueous humour, which is caused by an increase in capillary pressure in the ciliary body, thereby increasing the intravascular pressure and IOP gradient; second, decreasing the absorption of aqueous humour due to an increase in episclera venous pressure which obstructs return flow of aqueous humour.12 18 Through this mechanism, HTN increases the IOP, which causes mechanical stress on the lamina cribrosa in the posterior segment of the eye and results in damage to the axons and optic nerve fibres, thus developing OAG. In addition, Cantor et al9 13 19 20 reported that in hypertensive patients, glaucoma damage could occur due to the ischaemic optic nerve or RGCs due to decreased perfusion pressure. Although eye blood flow has an autoregulation process to ensure adequate irrigation of the eye tissue, changes in the production of endothelin-1 levels in patients with HTN lead to disruption of the vascular dysfunction process that can interfere with this process. In a cohort study conducted by Kawasaki et al, for 10 years, it has been reported that HTN causes a narrowing of the calibre of the central retinal artery (CRA), which results in impaired flow to the eye, especially in the ocular nerve head and lamina cribrosa and triggers glaucoma.21
Memarzadeh et al reported that in younger patients HTN exert a protective effect by increasing OPP. However, Memarzadeh et al 11 giving the exception of older patients, this protective effect is lost as a result of the morphological changes in the blood vessels caused by prolonged systemic HTN and resulting in impaired oxygen and nutrient supply. In systemic hypertensive patients, a chronic increase in BP is at risk of causing arteriosclerosis, changes in precapillary arteriolar size leading to increased resistance to blood flow and resulting in decreased perfusion in the posterior segment of the eye, thereby counteracting the protective effect prevailing at younger ages.22
In summary, the relationship between HTN as a risk factor for glaucoma has several mechanisms: (1) the presence of mechanical stress on the lamina cribrosa as a result of an increase in IOP caused by an increase in the production of aqueous humour by an increase in blood flow in the ciliary body and a decrease in the absorption of aqueous humour due to an increase in episclera venous pressure; (2) autoregulation disorders resulting from an imbalance in endothelin-1 levels; (3) narrowing of the calibre of the CRA due to chronic HTN, which causes blood flow to the eyes and (4) the incidence of atherosclerosis in chronic HTN, which also results in narrowing of the calibre of the CRA (figure 5).17–20 22
The mechanism of the role of hypertension on the risk of open-angle glaucoma.
In contrast to the previous results, Ishikawa et al23 reported that a lower diastolic blood pressure (DBP; ≤58 mm Hg) had an OR of 2.08 (1.21–5.45) than normal DBP to the incidence of OAG. Correspondingly, Memarzadeh et al also reported that the lower diastolic pressure (≤60 mm Hg) has an OR of 1.90 (1.1–3.0). Hulsman et al also reported that a decrease in diastolic perfusion pressure showed a significant association with the incidence of htOAG (high tension OAG) with IOP>21 mm Hg. This is closely related to the mean ocular perfusion pressure (MOPP), which is the pressure gradient between mean arterial pressure (MAP) and IOP. In the formula (MOPP= 
– IOP), we can conclude that MAP has a positive (+) relationship with MOPP. In contrast, the IOP has a (–) relationship with MOPP. In addition, from the MAP formula (
), it can be seen that DBP has a 2× more effect than systolic in the MAP calculation. This could explain why a decrease in DBP can to have an effect on reducing perfusion pressure in the eye, which results in the risk of OAG. These results lead to the assumption that people who have unstable DBP, either high DBP or low DBP, are both able to increase the risk of OAG events. However, none of the included studies reported a specific association between systolic BP and the incidence of OAG.11 13 However, none of the included studies reported a specific association between systolic BP and the incidence of OAG.
Apart from all the previous explanations, we realise that there are still many shortcomings in this study, one of which is because it does not review the treatment for HTN, this is because the included study did not report on this matter, so further research is still needed. From these results, we recommend conducting clinical trials on the effect of antihypertensive drugs in preventing and slowing the progression of OAG.
Conclusion
Based on this systematic review, it can be concluded that HTN increases the risk of OAG. However, several studies explain that low DBP also increases the risk of OAG, so there is a U-shaped effect between DBP and OAG.
The results of this systematic review are an update of existing results with a focus on the relationship between HTN and OAG, which are expected to be the basis of clinical practice by paying special attention to hypertensive patients who are at risk of developing OAG.
Data availability statement
No data are available.
Ethics statements
Patient consent for publication
Ethics approval
The study in question was not submitted to local ethical committee for approval since it involved a retrospective chart review of patients from existing literature and qualifies for exempt status under human subject regulations in our opinion.
Acknowledgments
We thank those who have helped in the process of compiling this review; Department of Ophthalmology, Hasanuddin University and Faculty of Medicine, Hasanuddin University. To the team who are always enthusiastic in compiling this review, to Indah Nurul Khairunnisa in the process of perfecting the use of language in this review.
References
Footnotes
Contributors RN had the same contribution as AT, both of whom were involved in all stages, drafting the concept, determining eligibility criteria, literature searching, study screening, data collection, quality assessment, statistical analysis, interpretation the result and draft writing. AI and NW were involved in drafting the concept and critical revision of the article. FK was involved in drafting the article and final approval of the version to be published. AM was involved in the study screening process, data collection and quality assessment. In the process of making this article, the second author (corresponding) has equally contributed with first author.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.